grant
Molecular and Cellular Dissection of Circadian Output Pathways in Drosophila
Organization LOYOLA UNIVERSITY OF CHICAGOLocation CHICAGO, UNITED STATESPosted 10 May 2018Deadline 28 Feb 2029
NIHUS FederalResearch GrantFY2026AffectAffective DisordersAllatostatinAnatomic SitesAnatomic structuresAnatomyAtlasesBehaviorBehavior ControlBehavioralBehavioral ManipulationBrainBrain Nervous SystemCancersCardiometabolic DiseaseCardiometabolic DisorderCell BodyCell CommunicationCell Communication and SignalingCell InteractionCell SignalingCell-to-Cell InteractionCellsCharacteristicsCircadian DysregulationClampingsClosure by clampCommunicationCuesCyclicityDataData SetDegenerative Neurologic DisordersDeveloped CountriesDissectionDiureticsDrosophilaDrosophila genusDrosophila melanogasterElectrophysiologyElectrophysiology (science)EncephalonEndocrine Gland SecretionEnsureExhibitsGene ExpressionGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGenesGeneticHealthHigh temperature of physical objectHormonesImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodIncidenceIndustrialized CountriesIndustrialized NationsIntracellular Communication and SignalingLateralLocomotor ActivityMalignant NeoplasmsMalignant TumorMammaliaMammalsMolecularMood DisordersMotor ActivityNerve CellsNerve Impulse TransmissionNerve TransmissionNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuronal TransmissionNeuronsNeuropeptidesNeurophysiology / ElectrophysiologyNeurosciencesOrganismOutcomeOutputPathway interactionsPatternPeriodicityPersonsPhysiologicPhysiologic pulsePhysiologicalPopulationPost-Transcriptional Gene SilencingProcessPropertyPulseRNA InterferenceRNA SeqRNA SilencingRNA sequencingRNAiRNAseqResearchRhythmicitySequence-Specific Posttranscriptional Gene SilencingSignal TransductionSignal Transduction SystemsSignalingSignaling MoleculeSynapsesSynapticSystemTemperatureTestingTimeTranscript Expression AnalysesTranscript Expression AnalysisTransmissionWith lateralityWorkanalyze gene expressionaxon signalingaxon-glial signalingaxonal signalingbehavior responsebehavioral controlbehavioral responsebiological signal transductioncancer riskcircadiancircadian abnormalitycircadian biologycircadian clockcircadian disruptioncircadian disturbancecircadian dysfunctioncircadian impairmentcircadian pacemakercircadian regulationconnectomedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdeveloped countrydeveloped nationdeveloped nationsdisabledelectrophysiologicalexperienceexperimentexperimental researchexperimental studyexperimentsfruit flygene expression analysisgene expression assaygene manipulationgenetic manipulationgenetically manipulategenetically perturbglia signalingglial signalinghigh temperatureinsightinterestinternal controlknock-downknockdownliving systemmalignancymolecular clockneoplasm/cancernerve signalingneural signalingneurodegenerative illnessneuronalneuronal circuitneuronal circuitryneuronal signalingneurotransmissionnext generationnovelpatch clamppatch sequencingpatch-seqpatchseqpathwaysynapsetooltranscriptional profilingtranscriptome sequencingtranscriptomic sequencingtransmission process
Description preview
Project Summary
Most organisms exhibit ~24-hr rhythms under the control of an internal circadian timing system, and circadian
disruption is associated with severe health consequences including increased incidence of cancer, mood
disorders, and cardiometabolic and neurodegenerative diseases. Notably, up to 70% of people from
industrialized…
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