grant
Molecular Analysis of Kinetochore Function
Organization WHITEHEAD INSTITUTE FOR BIOMEDICAL RESLocation CAMBRIDGE, UNITED STATESPosted 1 May 2018Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2026Affinity ChromatographyBiochemicalBiologicalBirth DefectsCell BodyCell Cycle ArrestCell FunctionCell PhysiologyCell ProcessCell divisionCellsCellular FunctionCellular PhysiologyCellular ProcessChromosome SegregationChromosomesCongenital AbnormalityCongenital Anatomical AbnormalityCongenital DefectsCongenital DeformityCongenital MalformationDNADefectDeoxyribonucleic AcidDiagnosisDiseaseDisorderFailureGenesGoalsHumanIndividualInterphase CellKinetochoresLaboratoriesM PhaseMeiosisMicro-tubuleMicrotubule PolymerizationMicrotubulesMitosisMitosis StageMitotic spindleModern ManModificationMolecularMolecular AnalysisMolecular Modeling Nucleic Acid BiochemistryMolecular Modeling Protein/Amino Acid BiochemistryMolecular ModelsNon-dividing CellNondividing CellOpticsPhenotypePhysiologicPhysiologicalProteinsProteomicsResting CellRodSiteStructureSubcellular ProcessWorkaffinity purificationbiologiccancer progressionchromosome divisiondefined contributiongenetic approachgenetic informationgenetic strategymacromolecular assemblymeioticmolecular modelingneoplasm progressionneoplastic progressionopticalreconstitutereconstitutionscreeningscreeningssenescencesenescenttumor progression
Description preview
Project Summary/Abstract
The goal of my laboratory is to define the molecular mechanisms by which accurate cell division occurs. Our
efforts focus on the core cell division machinery, including the macromolecular kinetochore and the
microtubule-based mitotic spindle. Despite the central importance of the spindle and the kinetochore, the
molecular…
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