grant
Modulatory effects of a retinoid-related protein on intestinal endocrine cells
Organization COLUMBIA UNIVERSITY HEALTH SCIENCESLocation NEW YORK, UNITED STATESPosted 1 Sept 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY20253D cell culture3D cultureAP-1AP-1 Enhancer-Binding ProteinAP1AP1 proteinAblationActivator Protein-1AffectAgeAlimentary CanalAppetiteAppetite RegulationAreaAutoregulationB9 endocrine pancreasBasal Transcription FactorBasal transcription factor genesBody WeightCRE RecombinaseCell BodyCell CountCell DeathCell DifferentiationCell Differentiation processCell FunctionCell Growth in NumberCell LineageCell MultiplicationCell NumberCell PhysiologyCell ProcessCell ProliferationCellsCellular FunctionCellular PhysiologyCellular ProcessCellular ProliferationCellular biologyCessation of lifeClassificationComplexD-GlucoseDNA Molecular BiologyDataDeathDesire for foodDevelopmentDextroseDiabetes MellitusDietDigestive TractDiseaseDisorderDown-RegulationEndocrineEndocrine Gland SecretionEndocrine GlandsEndocrine OrgansEndocrine PancreasEndocrinologistEnhancer-Binding Protein AP1Enterobacteria phage P1 Cre recombinaseEnterocytesEnteroendocrine CellEnvironmentGI TractGIP receptorGLP-1Gastric Inhibitory PolypeptideGastrointestinal TractGastrointestinal tract structureGene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGeneral Transcription Factor GeneGeneral Transcription FactorsGenerationsGenesGlp-1GlucoseGlucose-Dependent Insulin-Releasing PeptideGlucose-Dependent Insulinotropic PeptideGlucose-Dependent Insulinotropic PolypeptideGoalsGoblet CellsHealthHigh Fat DietHomeostasisHormonalHormone secretionHormonesHumanHuman FigureHuman bodyIn VitroInsulin ResistanceIntermediary MetabolismIntestinalIntestinesIslands of LangerhansIslets of LangerhansKO miceKnock-out MiceKnockout MiceKnowledgeL CellsLeadLearningMeasuresMentorshipMetabolicMetabolic DiseasesMetabolic DisorderMetabolic ProcessesMetabolismMiceMice MammalsModern ManMolecular BiologyMucosaMucosal TissueMucous MembraneMurineMusNesidioblastsNull MouseOrganoidsPancreatic IsletsPaneth CellsPars endocrina pancreatisPathway interactionsPb elementPhasePhysiologicPhysiologicalPhysiological HomeostasisPhysiologyPopulationProductionProliferatingProteinsPublishingRegulationReportingResearch ProposalsResearch ResourcesResourcesRetinoic Acid AgentRetinoic Acid and DerivativesRetinoid Binding ProteinsRetinoidsRetinol Binding ProteinsRetinol-Binding Protein 1RoleSignal PathwaySiteSmall IntestinesSubcellular ProcessSystematicsTechnical ExpertiseTherapeuticTherapeutic HormoneThesaurismosisTrainingTraining ProgramsTranscription Factor AP-1Transcription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional RegulationTransgenic MiceUniversitiesVillusVitamin AWeightWritingabsorptionagesalimentary tractbacteriophage P1 recombinase Creblood glucose regulationbowelcareercareer developmentcell biologycell typecellular differentiationdesigndesigningdevelopmentaldiabetesdietarydietsdifferential expressiondifferentially expresseddigestive canalexperimentexperimental researchexperimental studyexperimentsfunctional genomicsgastric inhibitory peptidegastric inhibitory polypeptide receptorglucagon-like peptide 1glucagon-like polypeptidesglucose controlglucose homeostasisglucose regulationglucose-dependent insulinotropic polypeptide receptorhealth care burdenheavy metal Pbheavy metal leadhormonal secretionin vivoincretin hormoneinsightinsulin resistantinsulin secretioninsulin toleranceintestinal epitheliummetabolism disordermigrationmouse modelmultidisciplinarymurine modelnecrocytosisnovelpathwayresearch data disseminationresearch disseminationresponseskillssmall bowelsocial roletechnical skillsthree dimensional cell culturetraffickingtranscription factortranscriptional differencestranscriptomicstranslational investigatortranslational researchertranslational scientistweights
Description preview
PROJECT SUMMARY
The gastrointestinal tract is the largest endocrine organ in the human body. This is due to the presence of
intestinal endocrine cells, a scarce yet important cell lineage within the intestinal epithelium. The hormones
produced by these enteroendocrine cells (EECs) exert important metabolic actions including insulin secretion
and…
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