grant
Modulation of NOD Strain Diabetes by ENU-Induced Mutations
Organization UT SOUTHWESTERN MEDICAL CENTERLocation DALLAS, UNITED STATESPosted 13 Jun 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY20250-11 years old1-Ethyl-1-nitrosourea18 year old18 years of ageAccelerationAffectAllelesAllelomorphsAnimalsAntigenic DeterminantsApoptoticArchivesAssayAutoantigensAutoimmune DiabetesAutoimmune DiseasesAutologous AntigensB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellB9 endocrine pancreasBeta CellBinding DeterminantsBioassayBiological AssayBloodBlood Precursor CellBlood Reticuloendothelial SystemBody TissuesBreedingBrittle Diabetes MellitusCD152CD152 AntigenCD152 GeneCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCTLA 4CTLA-4 GeneCTLA4CTLA4 geneCTLA4-TMCachectin ReceptorsCas nuclease technologyCausalityCell BodyCell Communication and SignalingCell CountCell NumberCell SignalingCellsChildChild YouthChildhoodChildren (0-21)Clustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCodeCoding SystemCollaborationsComplexCryofixationCryopreservationCytotoxic T-Lymphocyte Protein 4Cytotoxic T-Lymphocyte-Associated Antigen 4Cytotoxic T-Lymphocyte-Associated Protein 4Cytotoxic T-Lymphocyte-Associated Serine Esterase-4DNADNA mutationDNase-I FootprintingDataData BasesDatabasesDate of birthDeoxyribonucleic AcidDevelopmentDiabetes MellitusDiseaseDisease remissionDisorderDocumentationDrugsENUEndocrine PancreasEpitopesEthylnitrosoureaEtiologyExhibitsExpenditureFemaleFrequenciesFunctional RNAFundingGenesGeneticGenetic ChangeGenetic DiseasesGenetic defectGenetic mutationGenetics-MutagenesisGenomeGenomic DNAGenotoxinsGenotypeGerm LinesGuidelinesHematopoietic Progenitor CellsHematopoietic stem cellsHumanIDDMImmuneImmune systemImmunesImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsInbred NOD MiceInbreedingIndividualInduced DNA AlterationInduced MutationInduced Sequence AlterationInfluentialsInsulin CellInsulin Secreting CellInsulin-Dependent Diabetes MellitusIntellectual PropertyIntracellular Communication and SignalingIonsIslands of LangerhansIslet CellIslets of LangerhansJuvenile-Onset Diabetes MellitusKetosis-Prone Diabetes MellitusKnock-outKnockoutLaboratoriesLightMapsMeasuresMedicalMedicationMeiosisMetabolicMethodologyMethodsMiceMice MammalsMissense MutationModern ManModificationMolecularMonitorMurineMusMutagenesisMutagenesis Molecular BiologyMutagensMutant Strains MiceMutationN-Ethyl-N-nitrosoureaN-ethyl-N-nitroso-ureaN-terminalNH2-terminalNOD MouseNational Institutes of HealthNesidioblastsNitrosoethylureaNon obeseNon-Obese Diabetic MiceNoncoding RNANonobeseNonobese Diabetic MouseNontranslated RNANorth AmericaNucleotidesOrthologOrthologous GenePancreatic IsletsParisParis, FrancePars endocrina pancreatisPathogenesisPathogenicityPatientsPedigreePenetrancePeptidesPersonsPharmaceutical PreparationsPhenotypePhotoradiationPilot ProjectsPoint MutationPredispositionProgress ReportsProtein OverexpressionProteinsProteomicsPublicationsRNA SplicingRecoveryRegulatory T-LymphocyteRemissionResearch DesignResolutionResource SharingSamplingScientific PublicationSelf-AntigensSignal TransductionSignal Transduction SystemsSignalingSiteSplice-Junction MutationSplice-Site MutationSplicingStressStudy TypeSudden-Onset Diabetes MellitusSumSusceptibilityT cell receptor repertoire sequencingT cell receptor sequencingT cell responseT-CellsT-LymphocyteT-cell receptor repertoireT1 DMT1 diabetesT1DT1DMTCR repertoireTCR repertoire sequencingTCR sequencingTCR-seqTCRseqTNF Receptor Family ProteinTNF Receptor SuperfamilyTNF ReceptorsTNFRTechnologyTestingTherapeuticThymusThymus GlandThymus ProperThymus Reticuloendothelial SystemTissuesTregTumor Necrosis Factor ReceptorTumor Necrosis Factor Receptor FamilyTumor Necrosis Factor Receptor SuperfamilyType 1 Diabetes MellitusType 1 diabetesType I Diabetes MellitusUnited States National Institutes of HealthUntranslated RNAWorkWritingage 18 yearsanimationautoimmune conditionautoimmune disorderautoimmune reactivityautoimmunity diseaseautoreactivitybiological signal transductionblood cell progenitorblood progenitorblood stem cellblood-forming stem cellcausationcell typecold preservationcold storageconditional knock-outconditional knockoutcytotoxic T-lymphocyte antigen 4data basedata disseminationdevelopmentaldiabetesdiabetes pathogenesisdiabeticdisease causationdrug/agenteighteen year oldeighteen years of ageepigenetic regulationexome sequencingexome-seqforward geneticsgDNAgenetic conditiongenetic disordergenetic pedigreegenome mutationgenotoxic agentglobal gene expressionglobal transcription profilehematopoietic progenitorhematopoietic stem progenitor cellhemopoietic progenitorhemopoietic stem cellinsightinsulin dependent diabetesinsulin dependent type 1insulin sensitivityinsulitisjuvenile diabetesjuvenile diabetes mellitusketosis prone diabeteskidsmalemeetingmeetingsmeioticmembermissense single nucleotide polymorphismmissense single nucleotide variantmissense variantmolecular sequence databasemouse genomemouse mutantmutantnon-obese diabetic (NOD) micenoncodingnonobese diabetic (NOD) micenovelpediatricpedigree structurephospho-proteomicsphosphoproteomicspilot studypreventpreventingprotein protein interactionregulatory T-cellsresolutionsresponsescreeningscreeningssemen cryopreservationsequence databasesequencing databasesperm cell cryopreservationsperm cryopreservationsperm freezingspermatozoa cryopreservationstudy designsuccesstechnology platformtechnology systemthymus derived lymphocytetranscriptometranscriptomicstype I diabetestype one diabetesyoungsterβ-cellβ-cellsβCell♀♂
Description preview
PROJECT SUMMARY/ABSTRACT
This P01 proposal offers a fresh approach to understanding the genetics of an extremely important polygenic
autoimmune disease: type 1 diabetes (T1D), which affects nearly three children out of every thousand in North
America, and many more around the world. T1D occurs with variable penetrance in Non-Obese Diabetic (NOD)…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click