grant
Modulation of network dynamics across mood states using closed-loop deep brain stimulation for depression
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 1 Jul 2021Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2026AbscissionAffective DisordersAmygdalaAmygdaloid BodyAmygdaloid NucleusAmygdaloid structureAnteriorArtifactsBehaviorBehavior ControlBehavioralBehavioral ManipulationBiomedical EngineeringBrainBrain Nervous SystemCapsulesClinical EvaluationClinical TestingCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCommunicationComplementComplement ProteinsComplexConflictConflict (Psychology)CoupledDataData AnalysesData AnalysisData CollectionDeep Brain StimulationDiagnosisDiseaseDisorderDissectionDisturbance in cognitionDorsalDrug TherapyDysfunctionE-stimElectric Convulsive TherapyElectric Shock TherapyElectric StimulationElectric Stimulation TherapyElectroconvulsive PsychotherapyElectroconvulsive Shock TherapyElectroconvulsive TherapyElectroconvulsive treatmentElectrodesElectrophysiologyElectrophysiology (science)Electroshock PsychotherapyElectroshock TherapyElectroshock treatmentElectrotherapyEncephalonEnsureExcisionExertionExperimental DesignsExtirpationFrequenciesFunctional disorderGoalsGrainHumanImpaired cognitionImpairmentImplanted ElectrodesInvestigatorsKnowledgeMajor Depressive DisorderMeasurementMeasuresMental DepressionMental ProcessesMental disordersMental health disordersModern ManMood DisordersMoodsMorphologic artifactsNeurophysiology / ElectrophysiologyNeurosciencesOutcomeParentsParticipantPatient Self-ReportPatientsPharmaceutical AgentPharmaceuticalsPharmacologic SubstancePharmacological SubstancePharmacological TreatmentPharmacotherapyPhasePhysiopathologyPopulationPostdocPostdoctoral FellowPrefrontal CortexPsychiatric DiseasePsychiatric DisorderPsychotherapyR-Series Research ProjectsR01 MechanismR01 ProgramRemovalResearchResearch AssociateResearch GrantsResearch PersonnelResearch Project GrantsResearch ProjectsResearch ProposalsResearchersResistanceRestRodent ModelRoleScheduleSelf-ReportSourceStimulusStructureSurgical RemovalSymptomsTechniquesTestingTherapeuticTherapeutic Electric StimulationThinkingTrainingVentral StriatumWorkamygdaloid nuclear complexbehavioral controlbehavioral impairmentbio-engineeredbio-engineersbioengineeringbiological engineeringcapsulecareercell typecingulate cortexclinical depressionclinical testcognitive controlcognitive dysfunctioncognitive enhancementcognitive losscomplementationcomputational neurosciencedata interpretationdepressiondisabilitydrug interventiondrug treatmentelectric shock treatmentelectrical stimulation therapyelectro-convulsive therapyelectrophysiologicalelectroplexy shock therapyelectrostimulationelectrostimulation therapyexecutive controlexecutive functionexperimentexperimental researchexperimental studyexperimentsflexibilityflexiblehuman subjectideationimpaired behaviorimprovedinterdisciplinary approachmajor depressionmajor depression disordermental illnessmulti-modalitymultidisciplinarymultidisciplinary approachmultimodalityneuralneural circuitneural circuitryneural controlneural mechanismneural regulationneurocircuitryneuromechanismneuromodulationneuromodulatoryneurophysiologicalneurophysiologyneuropsychiatric diseaseneuropsychiatric disorderneuroregulationnovelparentpathophysiologypharmaceuticalpharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspost-docpost-doctoralpost-doctoral traineepsychiatric illnesspsychological disorderrecruitresearch associatesresearch clinical testingresectionresistantruminateruminationruminativeshock treatmentsocial rolesynaptic circuitsynaptic circuitrytask analysistherapy optimizationthoughtstooltreatment optimizationtreatment-refractory depressiontreatment-resistant depression
Description preview
Major Depressive Disorder (MDD) is a prevalent and debilitating disorder, where one-third of this
population is treatment-resistant. Depression is characterized by cognitive dysfunction, including deficits in
cognitive control, defined as flexible adaptation of cognitive and behavior commensurate with one’s current
goals. Application of deep brain…
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