grant
Modulation of Human Cells by Virulent Francisella tularensis
Organization NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY2025Acellular VaccinesAcuteAerosolsAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryBacteriaBacterial InfectionsBacterial O AntigenBreakbone Fever VirusCapsulesCarbohydratesCell BodyCellsDENVDangerousnessDataDeath RateDefectDendritic CellsDengue VirusDengue fever virusDevelopmentDiseaseDisorderF tularensisF tularensis infectionF. tularensisF. tularensis infectionFrancisellaFrancisella infectionFrancisella tularensisFrancisella tularensis infectionGoalsHealthHumanImmune responseImmune systemImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImpairmentIn VitroIncubatedIndividualInfectionInfectious AgentInflammationInflammatoryInflammatory ResponseInhalationInhalingInnate ImmunityIntermediary MetabolismInvadedLaboratoriesLegal patentLipid Synthesis PathwayLipidsLiposomalLiposomesMacrophageMediatingMembraneMetabolicMetabolic PathwayMetabolic ProcessesMetabolismMiceMice MammalsMicrobeModern ManMurineMusMφNative ImmunityNatural ImmunityNon-Specific ImmunityNonspecific ImmunityO AntigensO-Specific PolysaccharidesPasteurella tularensisPatentsPathogenicityPlayPredispositionProteinsPulmonary tularemiaReceptor ProteinResearchRoleRouteSREBP control of lipid synthesisSecondary toSentinelSignal PathwaySignaling MoleculeSoviet UnionSterol regulatory element binding protein control of lipid synthesisSterol response element binding protein control of lipid synthesisStimulusStructureSurfaceSusceptibilitySymptomsTestingTherapeuticTimeTransmissionTularemiaUSSRUnion of Soviet Socialist RepublicsUnited StatesVeiled CellsVirulenceVirulentadaptive immunitybacteria infectionbacteria pathogenbacterial diseasebacterial pathogenbiological weaponbioweaponcapsulecarbohydrate structurecell killingcytokinedevelopmentalhost responseimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive responsein vivoinfected with F tularensisinfected with F. tularensisinfected with Francisella tularensisinfectious organisminhalation of F tularensisinhalation of F. tularensisinhalation of Francisella tularensismembrane structuremortality ratemortality ratiomutantnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynew vaccinesnext generation therapeuticsnext generation vaccinesnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapynovel vaccinespathogenpathogenic bacteriapneumonic tularemiapreventpreventingprogramspulmonary Francisella Tularensisreceptorrespiratory tularemiaresponsesocial roletransmission processvector-bornevectorborneweapons
Description preview
Francisella tularensis (FT), the causative agent for tularemia, can infect humans by a number of routes, including vector-borne transmission. However, it is inhalation of the bacterium, and the resulting pneumonic tularemia, that represents the most dangerous form of disease. This is due to the short incubation time (3-5 days), non-specific…
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