grant
Modulating the resolution of angiogenesis and normalization of the vasculature for therapeutic benefit
Organization UNIVERSITY OF MARYLAND BALTIMORELocation BALTIMORE, UNITED STATESPosted 15 Jan 2025Deadline 30 Nov 2028
NIHUS FederalResearch GrantFY20257B4 Antigen7B4 proteinAccelerationAddressAdeno-Associated VirusesAdherens JunctionAdhering JunctionAdhesionsAdhesive JunctionAffectAnchoring JunctionAortaAssayB16F10BioassayBiochemistryBiological AssayBiological ChemistryBleedingBlood Coagulation Factor IBlood Coagulation Factor OneBlood Factor OneBlood VesselsBlood flowBody TissuesCD105CD105 AntigenCD105 GeneCD144 AntigenCancersCardiovascular DiseasesCell BodyCell Communication and SignalingCell JunctionsCell LocomotionCell MigrationCell MovementCell SignalingCellsCellular MigrationCellular MotilityCellular biologyCoagulation Factor ICoagulation Factor OneControl AnimalCoupledCustomDNA Molecular BiologyDataDefectDependoparvovirusDependovirusDepositDepositionDiseaseDisorderDropsyDrug DeliveryDrug Delivery SystemsEND GeneENG geneEdemaEndoglinEndoglin GeneEndothelial CellsEndotheliumFactor IFactor OneFailureFibrinFibrinogenG-ProteinsGTP-Binding ProteinsGTP-Regulatory ProteinsGene DeliveryGene ExpressionGeneralized GrowthGoalsGrowthGrowth AgentsGrowth FactorGrowth SubstancesGuanine Nucleotide Coupling ProteinGuanine Nucleotide Regulatory ProteinsHHT1HHT1 GeneHemorrhageHumanHydropsImpairmentIn VitroIncidenceIntercellular JunctionsIntracellular Communication and SignalingIschemiaMalignant MelanomaMalignant NeoplasmsMalignant TumorMediatingMelanomaMembraneMetabolicMiceMice MammalsModelingModern ManMolecularMolecular BiologyMorbidityMorbidity - disease rateMotilityMurineMusORW GeneORW1ORW1 GeneOutcomeOutcomes ResearchPAR-2 ReceptorPAR2 ReceptorPRSS21 gene productPathway interactionsPeripheral arterial diseasePhaseProcessProgenitor CellsProtease-Activated Receptor 2Proteinase Activated Receptor 2Proteins Growth FactorsRegulationResearchResolutionSerine EndopeptidasesSerine ProteaseSerine Protein HydrolasesSerine ProteinasesSerotypingSeveritiesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingStimulusTechniquesTestingTherapeuticTimeTissue GrowthTissuesTransforming Growth Factor P Receptor IIITreatment EfficacyTrypsin ReceptorTubeVE-CadherinVEGFVEGFsVascular Endothelial CadherinVascular Endothelial Cadherin 1Vascular Endothelial CellVascular Endothelial Growth FactorsVascular EndotheliumVascular blood supplyVascularizationadeno associated virus groupangiogenesisangiogenesis therapyassess effectivenessbiological signal transductionblood lossblood supplycadherin 5cardiovascular disordercell biologycell motilitycompare to controlcomparison controlcustomsdesigndesigningdetermine effectivenessdiabetic wound healingeffective therapyeffective treatmenteffectiveness assessmenteffectiveness evaluationevaluate effectivenessexamine effectivenessexperimentexperimental researchexperimental studyexperimentsextracellular vesiclesin vivoinsightintervention efficacymalignancymembrane structuremortalitymouse modelmurine modelneoplasm/cancerneovasculaturenew growthnovelontogenypathwayperipheral artery diseasepromoterpromotorrepairrepairedresolutionsresponserestorationstandard of carestem cellssuccesstestisintherapeutic angiogenesistherapeutic efficacytherapeutic evaluationtherapeutic testingtherapy efficacytissue repairtumortumor xenograftvascularvascular bedvascular supply
Description preview
Cardiovascular diseases are a leading cause of morbidity and mortality worldwide. Defective vascular repair or
insufficient vascularization after disrupted or blocked blood flow often lead to ischemic peripheral artery diseases
and other cardiovascular disorders. Treatment options generally aim to re-establish blood flow through affected
vascular…
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