grant
Modular, degradable, polymeric nanoparticles for the treatment of phagocyte-mediated diseases
NIHUS FederalResearch GrantFY20250-4 weeks oldAddressAffectAminesAntibodiesAreaAutoimmune hemolytic anemiaB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBiodistributionBiologicalBiologyBlood NeutrophilBlood Polymorphonuclear NeutrophilBlood erythrocyteBlood monocyteBody TissuesChargeChemicalsClinical Treatment MoabColoring AgentsData AnalysesData AnalysisDeath RateDendritic CellsDevelopmentDiseaseDisorderDoseDown-RegulationDrug DeliveryDrug Delivery SystemsDrugsDyesDysfunctionEPH- and ELK-Related Tyrosine KinaseEPH-and ELK-Related KinaseEngineeringEnvironmentEphrin Type-A Receptor 8Ephrin Type-A Receptor 8 PrecursorErythrocytesErythrocyticErythrocytophagyErythrophagiaErythrophagocytosisEstersExhibitsFetusFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFormulationFunctional disorderGoalsHealthHepaticHydrophobic SurfacesImage CytometryImmuneImmunesImmunoblottingImmunomodulationIn VitroInfusionInfusion proceduresInvestigationInvestigatorsKupffer CellsLabelLaboratoriesLiverMacrophageMarrow NeutrophilMarrow erythrocyteMarrow monocyteMediatingMediatorMedicalMedicationMedicineMentorshipMiceMice MammalsModalityModelingModificationMonoclonal AntibodiesMorbidityMorbidity - disease rateMurineMusMφNeutrophilic GranulocyteNeutrophilic LeukocyteNewborn InfantNewbornsNucleic AcidsOrganPatientsPhagocytesPhagocytic CellPhagocytosisPhagocytosis InhibitionPharmaceutical PreparationsPhenotypePhysiciansPhysiopathologyPolymersPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPopulationPositionPositioning AttributePrevalenceProcessPropertyProtein Tyrosine KinaseProtein Tyrosine Kinase EEKProteinsRNA SequencesReactionRed Blood CellsRed CellRed PulpRefractory DiseaseRelapseReportingResearch PersonnelResearchersResidualResidual stateResistanceReticuloendothelial SystemSYKSYK geneScientistShort interfering RNASiteSmall Interfering RNASpecificitySpleenSpleen Reticuloendothelial SystemSpleen Tyrosine KinaseSplenic Red PulpStellate Sinusoidal MacrophageTechniquesTechnologyTherapeuticTherapeutic antibodiesTissuesTrainingTraining ProgramsTransfusionTranslationsTropismTyrosine KinaseTyrosine-Protein Kinase Receptor EEKTyrosine-Protein Kinase SYKTyrosine-Specific Protein KinaseTyrosylprotein KinaseVeiled CellsWestern BlottingWestern ImmunoblottingWorkamebocyteamineanalytical methodbiologicblood corpusclescareercytopeniadata acquisitiondata acquisitionsdata interpretationdeliver short interfering RNAdeliver siRNAdeliver small interfering RNAdelivery system for siRNAdelivery system for small interfering RNAdelivery vectors for siRNAdesigndesigningdevelopmentaldrug developmentdrug/agentflow cytophotometryfluorescence imagingfluorescent imaginghepatic body systemhepatic organ systemhydroxyaryl protein kinaseimmune modulationimmune regulationimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryin vivoinfusionsinsightknock-downknockdownknowledge integrationliver macrophagemAbsmonoclonal Absmonocytemortalitymortality ratemortality ratiomouse modelmurine antibodymurine modelnano particlenano particle deliverynano polymernano-sized particlenanoparticlenanoparticle deliverednanoparticle deliverynanoparticle drugnanopolymernanosized particleneutrophilnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynewborn childnewborn childrennext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapynucleasenucleic acid deliverynucleic acid therapynucleic acid-based therapeuticspathophysiologyphysical propertypolymerpolymericpre-clinicalpreclinicalpreservationprotein blottingresistantshort interfering RNA deliverysiRNAsiRNA deliverysiRNA therapysiRNA-based therapeuticsiRNA-based therapyskillssmall interfering RNA deliverysmall moleculetherapeutic nucleic acidstherapeutic siRNAtherapeutic small interfering RNAtransfusion medicinetranslationtyrosyl protein kinaseuptake
Description preview
PROJECT SUMMARY/ABSTRACT
Nanoparticle (NP) drug delivery systems enable the protection of therapeutic cargoes with tunable target
specificity. Polymeric NPs exhibit phagocytic tropism, accumulating in the reticuloendothelial system of the liver
and spleen. This property is a barrier to non-phagocyte drug delivery but a boon for the development of…
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