grant
Modifying adipocyte and pre-adipocyte cell fate in fibroadipose tissue of secondary lymphedema
Organization BRIGHAM AND WOMEN'S HOSPITALLocation BOSTON, UNITED STATESPosted 1 Mar 2023Deadline 28 Feb 2028
NIHUS FederalResearch GrantFY2025AchievementAchievement AttainmentAddressAdipocytesAdipose CellAdipose tissueAffectAgonistApoptosisApoptosis PathwayApoptoticAutologousAvandiaAwardBioinformaticsBiologyBody TissuesCancer PatientCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesCell BodyCell Communication and SignalingCell DifferentiationCell Differentiation processCell SignalingCell SurvivalCell TherapyCell ViabilityCellsChronicClinicalDataDecline in mobilityDecrease in mobilityDecreased mobilityDepositDepositionDevelopment and ResearchDiminished mobilityDysfunctionEducational workshopEngineeringEngraftmentEnvironmentEvaluationExtremitiesFaceFat CellsFatsFatty TissueFatty acid glycerol estersFunctional disorderFundingGoalsHindlimbHistologicHistologicallyImpairmentInstitutionIntracellular Communication and SignalingK-AwardsK-Series Research Career ProgramsKO miceKnock-out MiceKnockout MiceLaboratoriesLeadershipLimb structureLimbsLineage TracingLipocytesLocal TherapyLocalized TherapyLymphLymphaticLymphedemaMAP kinase kinase kinase 7MAP3K7MAP3K7 geneMapsMature LipocyteMature fat cellMechanicsMediatorMentorsMentorshipMesenchymalMiceMice MammalsMicroRNAsMobility declineMobility impairmentModificationMonitorMurineMusNon-TrunkNull MouseObesityOperative ProceduresOperative Surgical ProceduresPathogenesisPathologicPathologyPatientsPhysiciansPhysiopathologyPlastic Surgical ProceduresPopulationPredispositionProcessProgenitor CellsProgrammed Cell DeathProliferatingPublic HealthQOLQuality of lifeR & DR&DRNA SeqRNA sequencingRNAseqReceptor ProteinReduced mobilityReduction in mobilityResearchResearch Career ProgramSalariesScientistSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSiteSurgicalSurgical InterventionsSurgical ProcedureSusceptibilitySwellingTAK1TAK1aTAK1bTAK1cTAK1dTGF-Beta Activated Kinase 1TGF-beta-activated kinase 1TamoxifenTechnical ExpertiseTherapeuticTimeTissuesTrainingTranslational ResearchTranslational ScienceUnited StatesWagesWorkshopadipocyte biologyadipocyte developmentadipocyte differentiationadiposeadiposityadverse consequenceadverse outcomeantagonismantagonistbiological signal transductioncareercell based interventioncell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcell mediated interventioncell mediated therapiescell typecell-based therapeuticcell-based therapycellular differentiationcellular lineage mappingcellular lineage trackingcellular therapeuticcellular therapychronic painconferenceconventioncorpulenceexosomeexpectationexperiencefacesfacialgene signaturesgenetic signatureinhibitorinsightlymph edemalymphatic edemalymphatic fluidmechanicmechanicalmiRNAmitogen-activated protein kinase kinase kinase 7mouse modelmurine modeloligonucleotide deliveryopen woundpathophysiologypharmacologicplastic surgerypreventpreventingprogenitor biologyprogenitor cell biologyprogenitor cell fateprogenitor cell poolprogenitor cell populationprogenitor fateprogenitor poolprogenitor populationreceptorresearch and developmentrosiglitazonescRNA sequencingscRNA-seqsecondary lymphedemasingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingskillsstem and progenitor biologystem and progenitor cell fatestem and progenitor cell populationstem cell biologystem cell fatestem cell poolstem cell populationstem cellssubcutaneoussubdermalsuccesssummitsurgerysymposiasymposiumtechnical skillstherapy adverse effecttranscriptome sequencingtranscriptomic sequencingtransforming growth factor-beta-activated kinase 1translation researchtranslational investigationtranslational medicinetranslational therapeuticstranslational therapytreatment adverse effecttreatment strategyuptakewhite adipose tissueyellow adipose tissue
Description preview
PROJECT SUMMARY
Secondary lymphedema is a morbid condition affecting over 5 million patients in the United States.
Patients with this condition develop lymphatic retention, which progresses to irreversible subcutaneous
fibroadipose deposition in the affected extremity. As a result, patients experience chronic pain, decreased
mobility and…
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