grant
Moderation of Aging Trajectories of Cognition and Neuropathology by Diet Composition in Middle-aged Nonhuman Primates
Organization WAKE FOREST UNIVERSITY HEALTH SCIENCESLocation WINSTON-SALEM, UNITED STATESPosted 15 Sept 2025Deadline 14 Sept 2029
NIHUS FederalResearch GrantFY2025AD dementiaAD related dementiaADRDAddressAdherenceAgingAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's and related dementiasAlzheimer's biomarkerAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease biological markerAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAlzheimer's disease riskAlzheimers DementiaAlzheimer’s biological markerAlzheimer’s disease biomarkerAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid Protein A4Amyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinArteriosclerotic DementiaAβBehaviorBiological MarkersBloodBlood PlasmaBlood Reticuloendothelial SystemBody TissuesBrainBrain Nervous SystemChronic DiseaseChronic IllnessClinical TrialsCognitionCognitive DisturbanceCognitive ImpairmentCognitive agingCognitive declineCognitive function abnormalConsumptionCrab-Eating MacaqueCrab-Eating MonkeyCynomolgus MonkeyCynomolgus macaqueDWI (diffusion weighted imaging)DWI-MRIDegenerative Neurologic DisordersDietDiet CompositionDietary InterventionDietary PracticesDiffusion MRIDiffusion Magnetic Resonance ImagingDiffusion Weighted MRIDiffusion weighted imagingDiffusion-weighted Magnetic Resonance ImagingDisturbance in cognitionDropsEncephalonExpression SignatureFatsFatty acid glycerol estersFemaleFishesFluid ShiftsFruitFutureGene Expression ProfileHealthHumanHyperinsulinemiaHyperinsulinismImageImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsImpaired cognitionImpairmentInflammationIntakeInvestigationLateralLightLiquid substanceLongitudinal StudiesM fascicularisM. fascicularisMR ImagingMR TomographyMRIMRIsMT-bound tauMacaca cynomolgusMacaca fascicularisMacaca irusMagnetic Resonance ImagingMeasuresMediationMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMediterranean DietMemoryMicro-tubuleMicrotubulesMidlife womenModelingModern ManMolecular TargetMonkeysNHP modelsNMR ImagingNMR TomographyNegotiatingNegotiationNerve DegenerationNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurobiologyNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuron DegenerationNuclear Magnetic Resonance ImagingNutrition InterventionsNutritional InterventionsPETPET ScanPET imagingPETSCANPETTParietal LobePathologicPathologic ProcessesPathological ProcessesPeptidesPersonsPhotoradiationPlasmaPlasma SerumPopulation StudyPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrefrontal CortexPreventionPrimary Senile Degenerative DementiaPrimatesPrimates MammalsRad.-PETReticuloendothelial System, Serum, PlasmaRiskRodentRodentiaRodents MammalsSocial isolationStructureStudy SubjectTemporal LobeTestingThickThicknessTimeTissuesTrainingUnhealthy DietVascular DementiaVegetablesWorkZeugmatographya beta peptideabetaaged brainaging brainaging resiliencealzheimer riskamyloid betaamyloid-b proteinanxiety-related behaviorbeta amyloid fibrilbio-markersbiologic markerbiomarkerbrain healthbuild resiliencebuild resiliencycerebrovascular contributions to dementiachronic disordercognitive abilitycognitive dysfunctioncognitive functioncognitive lossdMRIdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelop resiliencedevelop resiliencydiet interventiondietary compositiondietary fruitdietary patterndietary vegetabledietsdiffusion tensor imagingenhance resilienceenhance resiliencyfacilitate resiliencefemale at midlifefluidfruits and vegetablesgene expression patterngene expression signaturegray matterimage translationimagingimprove resilienceimprove resiliencyin vivoincrease resilienceincrease resiliencyinsightinterestlife spanlifespanliquidlong-tailed macaquelong-term studylongitudinal designlongitudinal experimental designlongitudinal outcome studieslongitudinal research designlongitudinal study designmalemicrotubule bound taumicrotubule-bound taumid lifemid-lifemid-life femalemiddle agemiddle agedmiddle-aged femalemiddle-aged womenmidlifeneuralneural degenerationneural imagingneural inflammationneuro-imagingneurobiologicalneurochemicalneurochemistryneurodegenerationneurodegenerativeneurodegenerative illnessneurofilamentneuroimagingneuroinflammationneuroinflammatoryneurological degenerationneurological imagingneuronal degenerationneuropathologicneuropathologicalneuropathologynew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynon-human primatenonhuman primatenonhuman primate modelsnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachp-taup-τparietal cortexphospho-tauphospho-τphosphorylated taupoor dietpopulation-based studypopulation-level studypositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypost-translational modification of tauposttranslational modification of taupreservationprimary degenerative dementiapromote resiliencepromote resiliencyradioligandresilienceresilience developmentresilience during agingresilience in agingresilience in normal agingresilience to agingresilience with agingresilientresilient agingresilient to agingresponsesaturated dietary fatsaturated dietary lipidsaturated fatsaturated lipidsenile dementia of the Alzheimer typesexsocial anxietysocially anxioussoluble amyloid precursor proteinstudies of populationsstudy of the populationsubstantia albasubstantia griseasugartautau Proteinstau factortau phosphorylationtau posttranslational modificationtau-1temporal cortextranscriptional profiletranscriptional signaturetreatment groupvascular contributions in dementiavascular contributions to dementiavascular related dementiawestern dietwestern-style dietwestern-type dietwhite matterwomen at midlifewomen in midlifeτ Proteinsτ phosphorylation♀♂
Description preview
PROJECT SUMMARY
Diet composition potently modulates trajectories of brain aging. Intake of a "Mediterranean" diet including fruit
and vegetables, fish, and healthy fats is associated with reduced risk of Alzheimer's disease and related
dementias including vascular dementia. Intake of a "Western" diet high in simple sugars and saturated fat is…
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