grant
Modeling ASD-linked genetic mutations in 3D human brain organoids
Organization HARVARD UNIVERSITYLocation CAMBRIDGE, UNITED STATESPosted 1 Feb 2018Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DASDASD patientAccelerationAffectAllelic LossAutismAutism Spectrum Disorder patientAutistic DisorderBinding ProteinsBiologyBrainBrain Nervous SystemBrain regionCalciumCell BodyCell Culture TechniquesCellsCerebral cortexChromatin Remodeling ComplexChromatin Remodeling FactorCollaborationsConnector NeuronDNA HelicasesDNA Unwinding ProteinsDNA mutationDNA unwinding enzymeDataDefectDevelopmentDorsalEarly Infantile AutismElectrophysiologyElectrophysiology (science)EncephalonEngineeringEquilibriumFore-BrainForebrainGenesGeneticGenetic ChangeGenetic defectGenetic mutationGenomicsGrantHeterozygoteHigh PrevalenceHumanHuman BiologyImageInfantile AutismIntercalary NeuronIntercalated NeuronsInterneuronsInternuncial CellInternuncial NeuronInvestigatorsKanner's SyndromeLateralLigand Binding ProteinLigand Binding Protein GeneLinkLoss of HeterozygosityMacrocephalyManuscriptsMedialMegacephalyMegalocephalyMiceMice MammalsModelingModern ManModernizationMolecularMurineMusMutateMutationNatureNerve CellsNerve UnitNeural CellNeurocyteNeurodevelopmental DisorderNeurological Development DisorderNeuronsNeurophysiology / ElectrophysiologyOrganoidsPharmacologyPhenotypePhysiologicPhysiologicalPhysiologyPluripotent Stem CellsPopulationPopulation AnalysisPredispositionPreparationPrintingProsencephalonProtein BindingReproducibilityResearch PersonnelResearchersRisk-associated variantRoleSusceptibilitySynapsesSynapticSystemTechnologyTelencephalonTestingWorkautism modelautism spectral disorderautism spectrum disorderautistic patientautistic spectrum disorderbalancebalance functionbound proteincell culturecell culturescell typechromatin modifierdevelopmentaldisease subgroupsdisease subtypedisorder subtypeelectrophysiologicalexcitatory neuronexperimentexperimental researchexperimental studyexperimentsextracellulargenome mutationhelicaseheterozygosityhuman modelimagingindividual heterogeneityindividual variabilityindividual variationinhibitory neuroninter-individual variabilityinter-individual variationloss of functionmodel of autism spectrum disordermodel of humanmulti-electrode arraysmultielectrode arraysmutantneuralneurodevelopmental diseaseneurogenesisneuron developmentneuronalneuronal circuitneuronal circuitryneuronal developmentnext generationpatient with ASDpermissivenesspharmacologicpluripotent progenitorpreparationsprogenitorrisk allelerisk generisk genotyperisk locirisk locusrisk variantsocial rolesynapsethree dimensional
Description preview
Project summary / Abstract
Autism spectrum disorder (ASD) is a neurodevelopmental disorder whose underlying mechanisms have been
proposed to include abnormal excitatory-inhibitory balance in brain regions including the cerebral cortex. The
ATP-dependent chromatin-remodeling factor chromodomain helicase binding protein 8 (CHD8) is one of the
most…
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