grant
Model Genetic Systems to Study DNA Repair
Organization NATIONAL INSTITUTE ON AGINGLocation UNITED STATES
NIHUS FederalResearch GrantFY2025Adult ProgeriaAlkylating AgentsAlkylatorsAutoregulationBasic ResearchBasic ScienceBiologic ModelsBiologicalBiological ModelsCancer TreatmentCancersCell BodyCell FunctionCell LineCell PhysiologyCell ProcessCellLineCellsCellular FunctionCellular PhysiologyCellular ProcessChickensChromosomal StabilityChromosome StabilitiesComplementComplement ProteinsCongenital PancytopeniaCritical PathsCritical PathwaysDNADNA DamageDNA Damage RepairDNA HelicasesDNA InjuryDNA RepairDNA Repair GeneDNA Repair PathwayDNA ReplicationDNA StructureDNA SynthesisDNA Unwinding ProteinsDNA biosynthesisDNA mutationDNA repair proteinDNA unwinding enzymeDeoxyribonucleic AcidDiagnosisDiseaseDisorderDrugsEmbryoEmbryonicEvolutionFanconi AnemiaFanconi PanmyelopathyFanconi dysplasiaFanconi's AnemiaFibroblastsG-QuadruplexG-Quadruplexes DNAG-Quartet StructuresG-QuartetsG-TetradsG4-DNAGallus domesticusGallus gallusGallus gallus domesticusGeneticGenetic ChangeGenetic DiseasesGenetic ModelsGenetic defectGenetic mutationGenomeGenome InstabilityGenome StabilityGenomic InstabilityGenomic StabilityGenotypeHelicase GeneHomeostasisHumanHuman Cell LineHuman GeneticsIndividualInhibition of Cell ProliferationKO miceKnock-out MiceKnockout MiceLinkMaintenanceMalignant CellMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMedicationMiceMice MammalsModel SystemModern ManMolecularMurineMusMutationNegative Control of Cell ProliferationNegative Regulation of Cell ProliferationNormal CellNull MouseOrthologOrthologous GenePathway interactionsPatientsPharmaceutical PreparationsPhenotypePhysiological HomeostasisPost-Transcriptional Gene SilencingPremature AgingPremature aging syndromePrimary Erythroid HypoplasiaRNA InterferenceRNA SilencingRNAiRadiationResistanceRoleSequence-Specific Posttranscriptional Gene SilencingStrains Cell LinesStressStructureSubcellular ProcessSystemUnscheduled DNA SynthesisWerner SyndromeWerner's syndromeWorkYeastsanti-cancer therapybiologiccancer cellcancer therapycancer-directed therapychemotherapyclinical relevanceclinically relevantcomplementationcongenital aplastic anemiacultured cell linedrug/agentgenetic conditiongenetic disordergenome mutationhelicasein vivoinsightmalignancymutantneoplasm/cancernovelpathwayrepairrepair functionrepairedreparative functionreplication stressresistantsmall moleculesocial roletumor
Description preview
Using an approach known as RNA interference, we have specifically depleted human cells of the FANCJ DNA helicase and characterized the sensitivity of the cells to a small molecule compound that stabilizes G-quadruplex DNA structures. This work enabled us to elucidate a novel function of the FANCJ helicase in the manintenace of chromosomal…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click