grant
Mitoprotective therapies for kidney injury
Organization UNIVERSITY OF TENNESSEE HEALTH SCI CTRLocation MEMPHIS, UNITED STATESPosted 15 Sept 2025Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025Acute Kidney FailureAcute Kidney InsufficiencyAcute Renal FailureAcute Renal InsufficiencyAddressAgonistAssayAutoregulationBasal Transcription FactorBasal transcription factor genesBioassayBioavailabilityBiochemicalBiologicalBiological AssayBiological AvailabilityCDDPCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCUT&RUNCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCas nuclease technologyCausalityCell BodyCell Culture TechniquesCell DeathCellsCellular biologyCharacteristicsCis-diammine-dichloroplatinumCis-diamminedichloridoplatinumCis-diamminedichloro Platinum (II)Cis-dichloroammine Platinum (II)Cis-platinous Diamine DichlorideCis-platinum IICis-platinum II Diamine DichlorideCisplatinCisplatinaCisplatinumCleavage Targets and Release Using NucleaseCleavage Under Targets and Release Using NucleaseClinicalClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyComplexCysplatynaDataDevelopmentDichlorodiammineplatinumDiseaseDisorderDrug KineticsDrug TherapyDrugsDysfunctionEpithelial CellsEtiologyFDA approvedFamily suidaeFunctional disorderGene DeletionGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic ScreeningGenetic TranscriptionGoalsHealthHeart VascularHigh Throughput AssayHomeostasisHospital AdmissionHospitalizationIn VitroInjuryInjury to KidneyInner mitochondrial membraneInternationalIschemiaKO miceKidneyKidney Urinary SystemKinasesKnock-out MiceKnockout MiceLesionManuscriptsMediatingMedicationMethodsMiceMice MammalsMitochondriaMitochondrial ProteinsModelingMolecularMolecular TargetMorbidityMorbidity - disease rateMovementMurineMusNamesNephrotoxicNull MouseOncologyOncology CancerOralPathologicPathway interactionsPatientsPeyrone's ChloridePeyrone's SaltPharmaceutical PreparationsPharmacokineticsPharmacological TreatmentPharmacotherapyPhasePhosphatidesPhospholipidsPhosphorylationPhosphotransferase GenePhosphotransferasesPhysiologic AvailabilityPhysiological HomeostasisPhysiopathologyPigsPlatinum DiamminodichloridePlayPropertyProtein PhosphorylationProteinsRNA ExpressionRecoveryRegulationRenal functionReperfusion TherapyReportingResearchRhabdomyolysisRho-associated kinaseRho-kinaseRiskRoleSepsisSeveritiesSpecificitySuidaeSwineTestingTherapeuticTherapeutic InterventionToxic effectToxicitiesTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTransphosphorylasesTubularTubular formationUpregulationZincZn elementabrogation of mitochondrial dysfunctionacute kidney injuryadverse consequenceadverse outcomealleviating mitochondrial dysfunctionameliorating mitochondrial dysfunctionattenuation of mitochondrial dysfunctionbiologicbody movementcausationcell biologycell culturecell cultureschemical geneticscirculatory systemcis dichlorodiammineplatinumcis platinum compoundcis-Diaminedichloroplatinumcis-Diamminedichloroplatinumcis-Diamminedichloroplatinum(II)cis-Dichlorodiammineplatinum(II)cis-Platinumclinical translationclinically translatabledetermine efficacydevelopmentaldisease causationdrug interventiondrug treatmentdrug/agentdruggable targetefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationefficacy studyevaluate efficacyexamine efficacyfunctional genomicsgene deletion mutationgenetic approachgenetic strategygenome wide screenhigh throughput screeninghuman diseasein vivoinjuriesintervention therapykidney functionkidney injurykidney toxicitykinase inhibitorlong-term sequelaemitigating mitochondrial impairmentmitochondrialmitochondrial dysfunctionmitochondrial rejuvenationmortalitymouse modelmurine modelnamenamednamingnecrocytosisnephrotoxicitynonspecific phospholipid transfer proteinsnovelpathophysiologypathwaypharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsphospholipid scramblasepig modelpiglet modelporcineporcine modelpre-clinicalpreclinicalpromoterpromotorprotective effectreducing mitochondrial dysfunctionrenalrenal injuryreperfusionsmall moleculesocial rolestemsuidsuppress mitochondrial dysfunctionswine modeltargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttranscription factor
Description preview
ABSTRACT
Acute kidney injury (AKI) is a common disease that is associated with adverse short and long-term sequelae.
AKI usually occurs in hospitalized patients and in the settings of other clinical conditions, such as sepsis,
rhabdomyolysis, and cardiovascular and oncological diseases, where the underlying disease and or associated
therapeutic…
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