grant
MitoPac female killing systems in mosquitoes
Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 19 Feb 2026Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2026A. aegyptiAddressAdes aegyptiAdvanced DevelopmentAe. AegyptiAedes aegyptiAnophelesAnopheles GenusAnophelinesAutomobile DrivingBiologyCRISPRCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas systemCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyClustered Regularly Interspaced Short Palindromic RepeatsClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCodeCoding SystemCoupledCulicidaeDNA Restriction EnzymesDataData SetDengueDevelopmentDevelopment and ResearchDisease VectorsDrosophilaDrosophila genusElementsEngineeringEnsureEssential GenesFeasibility StudiesFemaleFutureGene ExpressionGene TranscriptionGenesGeneticGenetic TranscriptionGenome engineeringGoalsHealthHeat ShockHeat-Shock ReactionHeat-Shock ResponseHumanInsectaInsectsInsects InvertebratesIntervening SequencesIntronsLocationMalariaMitochondriaMitochondrial DNAModelingModern ManMosquito ControlMosquito-borne diseaseMosquito-borne infectious diseaseMosquitoesOrthologOrthologous GenePaludismPhenotypePlasmodium InfectionsPolycombPopulationPopulation StudyR & DR&DRNA ExpressionRegulationRegulatory ElementResearchResponse ElementsRestriction EndonucleasesSex RatioSpecificitySystemTechnologyTemperatureTetracyclinesTimeToxinTranscriptionTransmissionWorkZIKV diseaseZika virus diseasechikungunyacold temperaturecommunicable disease transmissiondesigndesigningdevelopmentaldisease transmissiondrivingexpectationexperiencefitnessflexibilityflexiblefruit flygenetic technologyhuman pathogenimprovedinfectious disease transmissioninnovateinnovationinnovativelow temperaturemalemitochondrialmtDNAnovelpathogenpopulation research studypopulation surveypopulation-based studypopulation-level studypromoterpromotorresearch and developmentselective expressionselectively expressedsextech developmenttechnology developmenttimelinetooltransmission processvectorvector mosquitozika disease♀♂
Description preview
PROJECT SUMMARY
Dengue, chikungunya, and Zika are diseases transmitted by Aedes aegypti. One strategy to reduce Ae.
aegypti populations is to release non-biting male mosquitoes that pass female killing genes to their progeny.
Over time and with many releases, this can lead to a significant suppression of the mosquito population,
decreasing…
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