grant
Mitochondrial RNA Uridylation in Trypanosomes
Organization BOSTON UNIVERSITY MEDICAL CAMPUSLocation BOSTON, UNITED STATESPosted 21 Feb 2024Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY20265'-Exonuclease5'-NucleotidephosphodiesteraseAccountabilityAffectAfrica South of the SaharaAlkaline PhosphodiesteraseAlkaline Phosphodiesterase IAnti-sense RNAAntigen VariationAntigenic VariabilityAntigenic VariationBasic ResearchBasic ScienceBindingBiogenesisBiological FunctionBiological ProcessBiologyCatalytic CoreCatalytic DomainCatalytic RegionCatalytic SiteCatalytic SubunitChemistryCodeCoding SystemCollaborationsComplexCryo-electron MicroscopyCryoelectron MicroscopyDNA HelicasesDNA Unwinding ProteinsDNA unwinding enzymeDedicationsDevelopmentDiseaseDisorderDockingElectron CryomicroscopyEnzyme GeneEnzymesEukaryotaEukaryoteExonucleaseFliesFoundationsGenerationsGenomeGuide RNAHydrolysisImageIndividualKnowledgeLinkMammaliaMammalsMapsMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMaternal Messenger RNAMaternal mRNAMessenger RNAMetabolicMicroRNAsMitochondriaMitochondria RNAMitochondrial RNAModalityModernizationModificationMolecularMolecular InteractionMolecular MotorsNon-Polyadenylated RNAOligonucleate 5'-NucleotidohydrolaseOrigin of LifeOrthophosphoric Diester PhosphohydrolaseParasitesParasitic infectionPathway interactionsPhosphodiesterase IProcessProductionProteomicsProtozoaProtozoalPublic HealthRNARNA DecayRNA EditingRNA Gene ProductsRNA HelicaseRNA ProcessingRNA metabolismRNA, Messenger, EditingReactionResearch ResourcesResolutionResourcesRibonucleic AcidRibonucleoproteinsRibosomal RNARoentgen RaysRoleSiteStructureSub-Saharan AfricaSubsaharan AfricaT bruceiT. bruceiTailTechnologyTestingTrans RNA SplicingTrans-SplicingTranscriptTransfer RNATransferaseTransferase GeneTranslationsTriplet Codon-Amino Acid AdaptorTrypanosomaTrypanosoma bruceiTrypanosoma brucei bruceiTrypanosomeWorkX-RadiationX-Ray RadiationX-rayXrayclinical significanceclinically significantcombatcrosslinkcryo-EMcryoEMcryogenic electron microscopydevelopmentalepitranscriptomicsflygRNAhelicasehuman pathogenimagingin vivoindelinfected with parasitesinsertion/deletioninsertion/deletion mutationinsightloss of functionmRNAmarginalized groupmarginalized individualmarginalized peoplemarginalized populationmiRNAmitochondrialmtRNAparasite infectionparticlepathogenpathwayprotein complexrRNAresolutionssocial rolestructural determinantsstructural factorstRNAtransfer Ribonucleic acidstranslationuridylate
Description preview
SUMMARY
Parasitic infections by Trypanosoma brucei spp. undermine public health and economy in Sub-Saharan Africa.
From the basic science vantage point, discoveries of antigenic variation, trans-splicing, and RNA editing in these
early branching protozoans have contributed fundamental tenets of eukaryotic biology. Notably, work on
mitochondrial…
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