grant
Mitochondrial NAD+ in Acute Myeloid Leukemias
Organization UNIVERSITY OF TEXAS AT AUSTINLocation AUSTIN, UNITED STATESPosted 24 Aug 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY202565 and older65 or older65 years of age and older65 years of age or more65 years of age or older65+ years65+ years oldAML - Acute Myeloid LeukemiaAcute Myeloblastic LeukemiaAcute Myelocytic LeukemiaAcute Myelogenous LeukemiaAdjuvantAffectAged 65 and OverApoptosisApoptosis PathwayAreaBindingBinding SitesBiosensorBlood Precursor CellBone Marrow GraftingBone Marrow TransplantBone Marrow TransplantationBreast Cell GlutaminaseCancersCarbonCell BodyCell LineCellLineCellsChIP SequencingChIP-seqChIPseqCitric Acid CycleClinicalCombining SiteComplexConsumptionCytoplasmDNA NucleasesDNaseDataData SetDeoxyribonucleasesDependenceDihydronicotinamide Adenine DinucleotideDiphosphopyridine NucleotideDiseaseDisorderEC 3.5.1.2EnvironmentGA ProteinGeneticGlnGlutaminaseGlutamineHematopoietic Progenitor CellsHematopoietic stem cellsHeterograftHeterologous TransplantationHumanHypersensitivityImmune mediated therapyImmunologically Directed TherapyImmunotherapyIndividualIntermediary MetabolismKrebs CycleL glutamine amidohydrolaseL-GlutamineLiver GlutaminaseMalate-Aspartate Shuttle PathwayMalate-aspartate shuttleMalignant NeoplasmsMalignant TumorMammalian CellMarrow TransplantationMetabolicMetabolic PathwayMetabolic ProcessesMetabolismMitochondriaMitochondrial MatrixMitochondrial ProteinsModelingModern ManMolecularMolecular InteractionMutateMyelosuppressionNadideNatureNicotinamide adenine dinucleotideNicotinamide-Adenine DinucleotideOncogenesisOxidative PhosphorylationOxidative Phosphorylation PathwayPathway interactionsPatientsPhenotypeProductionProgrammed Cell DeathProliferatingProteinsPublishingQ LevoglutamideQ. LevoglutamideReactive SiteRecurrent diseaseRefractoryRegulationRelapseRelapsed DiseaseResearchResearch SpecimenResistance developmentResistant developmentRoleSamplingSourceSpecimenStrains Cell LinesSupplementationSurvival RateTCA cycleTestingTherapeuticTimeToxic effectToxicitiesTricarboxylic Acid CycleTumor BurdenTumor LoadTumor PromotionWorkXenograftXenograft procedureXenotransplantationabove age 65acute granulocytic leukemiaacute granulocytic leukemia cellacute myeloblastic leukemia cellacute myelocytic leukemia cellacute myelogenous leukemia cellacute myeloid leukemiaacute myeloid leukemia cellacute nonlymphocytic leukemia cellafter age 65age 65 and greaterage 65 and olderage 65 or olderageage groupage of 65 years onwardaged 65 and greateraged 65+aged groupaged groupsaged individualaged individualsaged peopleaged personaged personsaged populationaged populationsaged ≥65aging populationbiological sensorblood cell progenitorblood progenitorblood stem cellblood-forming stem cellc mycc-myc Genescancer cell metabolismcancer metabolismchemotherapychemotherapy induced neuropathychromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingcmyccombinatorialcultured cell linedeprivationdeveloping resistancedisease modeldisorder modelelderly patientfitnessglutamine addictionglutamine dependenceglutamine dependent cancerhematopoietic progenitorhematopoietic stem progenitor cellhemopoietic progenitorhemopoietic stem cellhuman old age (65+)immune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyin vivoinhibitormalignancymetabolism measurementmetabolomicsmetabonomicsmitochondrialmitochondrial metabolismmortalitymouse modelmurine modelneoplasm/cancerolder patientover 65 yearspathwaypopulation agingpromoterpromotorsocial roletherapeutic targettraittumor cell metabolismtumor metabolismtumorigenesisv-myc Avian Myelocytomatosis Viral Oncogene Cellular Homologxeno-transplantxeno-transplantation≥65 years
Description preview
PROJECT SUMMARY
Targeting mitochondrial metabolism is an active area of research in Acute Myeloid Leukemia (AML).
The cumulative data indicate that AML cells have heightened mitochondrial activity and prefer glutamine as a
carbon source compared to noncancerous cells. Nevertheless, a challenge that emerges when trying to target
these…
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