grant
Mitochondrial Function and Multiomics in Aging-related Disease: Identifying Novel Biomarkers and Causal Relationships
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 15 Aug 2024Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2026AccelerationActive OxygenApoplexyApoptosisApoptosis PathwayAutomobile DrivingBiological MarkersBlood PlasmaBrain Vascular AccidentCardiac infarctionCardiovascular DiseasesCausalityCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell RespirationCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessCellular RespirationCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeDNADNA copy numberDataDeoxyribonucleic AcidDiabetes MellitusDietary FactorsDrugsDyslipidemiasEnergy ExpenditureEnergy MetabolismEtiologyFree RadicalsFutureGWA studyGWASGenesGenetic DiversityGenetic VariationGenomeH2O2HealthHeart failureHereditaryHumanHydrogen PeroxideHydroperoxideHypertensionIndividualInheritedInterventionIntracellular Communication and SignalingLinkMapsMeasurableMeasurementMeasuresMediatingMediationMedicationMendelian randomizationMitochondriaMitochondrial DNAModelingModern ManMolecularMyocardial InfarctMyocardial InfarctionNegotiatingNegotiationNuclearOrganellesOxygen RadicalsParticipantPharmaceutical PreparationsPhenotypePhysical activityPlasmaPlasma SerumPlayPopulationPro-OxidantsProductionProgrammed Cell DeathProteinsProteomicsReactive Oxygen SpeciesReticuloendothelial System, Serum, PlasmaRiskRisk FactorsRoleSample SizeSamplingSignal TransductionSignal Transduction SystemsSignalingSingle Base PolymorphismSingle Nucleotide PolymorphismSiteStrokeSubcellular ProcessSuperoxide AnionSuperoxide RadicalSuperoxidesSystems BiologyTOPMedTestingTobacco ConsumptionTobacco useTrans-Omics for Precision MedicineValidationVariantVariationVascular Hypertensive DiseaseVascular Hypertensive Disorderaerobic metabolismaerobic respirationaging associatedaging associated diseaseaging associated disordersaging relatedaging related diseaseaging related disordersanti aging based therapeuticanti aging therapeuticanti-aging property therapeuticbio-markersbiobankbiologic markerbiological signal transductionbiomarkerbiorepositorybrain attackcardiac failurecardiac infarctcardiovascular disease riskcardiovascular disordercardiovascular disorder riskcausal allelecausal genecausal mutationcausal variantcausationcausative mutationcausative variantcerebral vascular accidentcerebrovascular accidentcoronary attackcoronary infarctcoronary infarctiondensitydiabetesdisease associated with agingdisease causationdisease of agingdisorder of agingdisorders associated with agingdisorders related to agingdrivingdrug/agententire genomefrailtyfull genomegene testinggene-based testinggenetic testinggenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studygeroscience therapeuticgerotherapeuticheart attackheart infarctheart infarctionheteroplasmyhigh blood pressurehyperpiesiahyperpiesishypertensive diseasehypertensive disorderinnovateinnovationinnovativeinstrumentlow-frequency mutationmalleable riskmetabolism measurementmetabolomicsmetabonomicsmitochondrialmitochondrial dysfunctionmodifiable riskmortalitymtDNAmultiomicsmultiple omicsnew markernovelnovel biomarkernovel markeroxidative metabolismpanomicsrare allelerare mutationrare variantsingle nucleotide variantsocial rolestrokedstrokestherapeutic against agingtherapeutic interventions against agingtherapeutic strategies for agingtherapeutic strategies targeting agingtherapeutic targettherapeutic target for anti-agingtherapeutic targeting agingtherapeutic targets to reverse agingtherapeutic to prevent agingtherapeutics impacts on agingtherapeutics that slow agingtobacco product usevalidationswhole genomewhole genome association analysiswhole genome association study
Description preview
Mitochondria play an essential role in cellular function and impact human health through varied mechanisms,
including energy metabolism, cell signaling, and apoptosis. We have previously demonstrated that mitochondrial
DNA copy number (mtDNA-CN), which reflects some aspects of mitochondrial function, can readily be measured
from DNA extracted from…
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