grant
Mitochondrial Fidelity in Mammalian Neurons
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 5 Aug 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025AgingAmino AcidsAmpullary CrestAnimalsArchitectureAutoregulationAxonBiogenesisBiologyBody TissuesBrainBrain Nervous SystemBuffersCalciumCell BodyCell DeathCell FunctionCell PhysiologyCell ProcessCellsCellular FunctionCellular PhysiologyCellular ProcessComplexCrista ampullarisDNADegenerative Neurologic DisordersDendritesDeoxyribonucleic AcidDockingEncephalonEnergy-Generating ResourcesEngineering / ArchitectureGene ExpressionGene ProteinsGliaGlial CellsGoalsHalf-LifeHeartHomeostasisImpairmentIntermediary MetabolismInvestigationKineticsKolliker's reticulumLabelLength of LifeLinkLongevityMaintenanceMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasuresMembraneMetabolicMetabolic ProcessesMetabolic Protein DegradationMetabolismMethodsMiceMice MammalsMicrofluidic DeviceMicrofluidic Lab-On-A-ChipMicrofluidic MicrochipsMitochondriaMitochondrial DNAMitochondrial ProteinsMitogenesisMolecularMolecular TargetMorphologyMurineMusNPCNerve CellsNerve DegenerationNerve UnitNervous System Degenerative DiseasesNervous System DiseasesNervous System DisorderNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurodevelopmental DisorderNeurogliaNeuroglial CellsNeurologic Degenerative ConditionsNeurologic DisordersNeurological Development DisorderNeurological DisordersNeuron DegenerationNeuronsNon-neuronal cellNonneuronal cellNuclearNuclear Pore ComplexOpticsOrganellesOrigin of LifePatternPhasePhysiologic pulsePhysiological HomeostasisPlayPositionPositioning AttributePositive Control of Cell ProliferationProcessProductionProtein BiosynthesisProtein Gene ProductsProtein TurnoverProteinsProteomeProteomicsPulseQuality ControlRegulatory Protein DegradationRejuvenationResearchResearch ProposalsRibo-seqRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRoleSiteStable Isotope LabelingStimulation of Cell ProliferationStructureSubcellular ProcessSynapsesSynapticTechniquesTissuesTranslationsTubularTubular formationabrogation of mitochondrial dysfunctionage associated neurodegenerationage associated neurodegenerative diseaseage associated neurodegenerative disorderage dependent neurodegenerationage dependent neurodegenerative conditionage dependent neurodegenerative diseaseage dependent neurodegenerative disorderage related neurodegenerationage-driven neurodegenerative disordersage-related neurodegenerative diseaseage-related neurodegenerative disorderaging associated neurodegenerationaging associated neurodegenerative diseaseaging related neurodegenerationaging related neurodegenerative diseaseaging related neurodegenerative disorderalleviating mitochondrial dysfunctionameliorating mitochondrial dysfunctionaminoacidattenuation of mitochondrial dysfunctioncrista ampullacristaedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesenergy sourceexperimentexperimental researchexperimental studyexperimentsfitnessfluorescence imagingfluorescent imaginggene manipulationgenetic manipulationgenetically manipulategenetically perturbgenome integritygenomic integrityinsightmembrane structuremicrofluidic chipmitigating mitochondrial impairmentmitochondria fitnessmitochondrialmitochondrial dysfunctionmitochondrial fitnessmitochondrial genomemitochondrial rejuvenationmtDNAnecrocytosisnerve cementneural degenerationneurodegenerationneurodegenerativeneurodegenerative illnessneurodevelopmental diseaseneurological degenerationneurological diseaseneuronalneuronal degenerationnovelopticalpostmitoticpreservationprotein degradationprotein synthesisreducing mitochondrial dysfunctionribosome footprint profilingribosome profilingsocial rolespatial and temporalspatial temporalspatiotemporalsuper high resolutionsuperresolutionsuperresolution microscopysuppress mitochondrial dysfunctionsynapsetranslationultra high resolution
Description preview
Summary
Mitochondria are multifaceted organelles that play vital roles in a myriad of cellular functions, including energy
production, metabolism, calcium homeostasis, and cell death. It is generally accepted that a decline in
mitochondria quality is a key contributor to mitochondrial dysfunction, aging, and represents a key point of
convergence…
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