grant

Mitochondrial factories for AMD therapy

Organization METHODIST HOSPITAL RESEARCH INSTITUTELocation HOUSTON, UNITED STATESPosted 1 May 2026Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2026ATP SynthesisATP Synthesis PathwayAccelerationActive OxygenAffectAgeAge related macular degenerationAge-Related MaculopathyAmericanAtrophic AMDAtrophic age-related macular degenerationBiochemicalBiodistributionBioenergeticsBiogenesisBlindnessBlood VesselsBody TissuesCell AgingCell BodyCell Communication and SignalingCell IsolationCell ReprogrammingCell RespirationCell SegregationCell SenescenceCell Senescence InductionCell SeparationCell Separation TechnologyCell SignalingCell TherapyCellsCellular AgingCellular RespirationCellular SenescenceCellular StressCellular Stress ResponseCommon Rat StrainsComplexDNA DamageDNA InjuryDataDiseaseDisorderDry AMDDrynessDysfunctionElectron TransportEnvironmentExhibitsEyeEyeballFunctional disorderGene ExpressionGene TranscriptionGeneralized GrowthGenetic TranscriptionGrowthHumanImpairmentInnate ImmunityIntercellular nanotubesIntracellular Communication and SignalingLaboratoriesLightMSC transplantationMesenchymal Progenitor CellMesenchymal Stem Cell TransplantationMesenchymal Stem CellsMesenchymal progenitorMesenchymal stromal/stem cellsMetabolicMethodsMiceMice MammalsMitochondriaMitochondrial DNAModelingModern ManMolecularMurineMusNaIO3Native ImmunityNatural ImmunityNon-Polyadenylated RNANon-Specific ImmunityNon-exudative age-related macular degenerationNonexudative age-related macular degenerationNonspecific ImmunityOrigin of LifeOutcomeOuter pigmented layer of retinaOxidative PhosphorylationOxidative Phosphorylation PathwayOxidative StressOxidative Stress InductionOxygen RadicalsPatientsPhotoradiationPhotoreceptor CellPhotoreceptorsPhotosensitive CellPhysiopathologyPigment cell layer of retinaPigmented layer of retinaPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPro-OxidantsProcessProductionProtein ModificationProteinsProteomicsRNARNA ExpressionRNA Gene ProductsRatRats MammalsRattusReactive Oxygen SpeciesReplicative SenescenceRespiratory ChainRetinaRetinal DegenerationRetinal Pigment EpitheliumRetinal pigment epithelial cellsRibonucleic AcidRodent ModelRoleSafetySignal TransductionSignal Transduction SystemsSignalingSourceStressStructure of retinal pigment epitheliumTestingTissue GrowthTissuesTranscriptionTransfectionTransplantationVisual ReceptorWorkaerobic metabolismaerobic respirationage associated effectsage dependent macular degenerationage effectage induced macular degenerationage related effectsage related macular diseaseage related macular dystrophyagedagesaging effectbiological signal transductioncell based interventioncell mediated interventioncell mediated therapiescell sortingcell stresscell-based therapeuticcell-based therapycellular aging inductioncellular reprogrammingcellular senescence inductioncellular therapeuticcellular therapydegenerative retina diseasesdry age-related macular degenerationeffective therapyeffective treatmentefficacy studyelectron transferengineered progenitor cellsengineered stem cellsextracellular vesiclesimpact of agein vivoinfluence of ageinsightmembrane nanotubesmembranous nanotubesmesenchymal stromal cellmesenchymal stromal progenitor cellsmesenchymal-derived stem cellsmitochondrialmitochondrial dysfunctionmtDNAnuclear respiratory factornuclear transfernuclear transplantationontogenyoverexpressoverexpressionoxidative metabolismpathophysiologyphotoreceptor degenerationprogenitor cell based therapyprogenitor cell therapyprogenitor cell treatmentprogenitor therapyprogenitor treatmentreplicative agingresponseretina degenerationretinal degenerativeretinal degenerative diseasessenescencesenescence inductionsenescentsenile macular diseasesocial rolesodium iodatestem and progenitor cell therapystem cell based therapystem cell mediated therapystem cell therapeuticsstem cell therapystem cell treatmentstem cell-based therapeuticstem cell-based treatmenttraffickingtranscriptomicstransplanttunneling nanotubesvascularvesicle releasevesicular releasevision lossvisual loss
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PROJECT SUMMARY
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness involving gradual
dysfunction and degeneration of photoreceptors and the retinal pigment epithelium (RPE). Mitochondrial
dysfunction represents a hallmark of AMD. Excessive and persistent reactive oxygen species (ROS) damages
mitochondrial DNA…

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Mitochondrial factories for AMD therapy — METHODIST HOSPITAL RESEARCH INSTITUTE | UNITED STATES | May 2026 | Dev Procure