grant
Mitigation of Gastrointestinal Damage
Organization COLUMBIA UNIVERSITY HEALTH SCIENCESLocation NEW YORK, UNITED STATESPosted 26 Aug 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY2025AcuteAcute Radiation SyndromeAddressAnimal EuthanasiaAnimal Mercy KillingAnimalsBiological MarkersBloodBlood PlasmaBlood Reticuloendothelial SystemBlood SerumBody SystemBody TissuesBone MarrowBone Marrow Reticuloendothelial SystemCollaborationsCollectionCombined Modality TherapyCommon Rat StrainsConventional X-RayDevelopmentDevicesDoseDose RateDrug DesignDrugsEuthanasiaEventExposure toFecesFemaleGastrointestinal InjuryHealthHealth StatusHeartHematopoieticHistologyHourIndividualInflammationInjuryIntestinalIntestinesInvestigationKidneyKidney Urinary SystemLevel of HealthLisinoprilLungLung Respiratory SystemLung damageMeasurementMeasuresMedicationMercy KillingModelingMonitorMultimodal TherapyMultimodal TreatmentNeutronsNuclearNuclear AccidentsOrganOrgan SystemOutcomePersonsPharmaceutical PreparationsPlasmaPlasma SerumPolypharmacyPopulationPrinivilRadiationRadiation AccidentsRadiation DoseRadiation Dose UnitRadiation InjuriesRadiation ToxicityRadiation exposureRadiotoxicityRatRats MammalsRattusReticuloendothelial System, Serum, PlasmaRodentRodentiaRodents MammalsRoentgen RaysSamplingSerumSimvastatinSiteSourceSurvivorsSynvinolinTestingTherapeutic InterventionTimeTissuesWorkX-RadiationX-Ray ImagingX-Ray Medical ImagingX-Ray RadiationX-rayXrayXray imagingXray medical imagingZestrilanimal tissuebio-markersbiologic markerbiomarkerbowelcardiac damagecohortcombination therapycombined modality treatmentcombined treatmentconventional Xrayconventional dosageconventional dosingdamage to kidneydetermine efficacydevelopmentaldrug/agentearly biomarkersearly detection biomarkersearly detection markersefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationevaluate efficacyexamine efficacygastrointestinalhealth levelheart damagehemopoieticimprovedinjuriesinjury to tissueintervention therapyirradiationirradiation injurykidney damagelung injurymalemortalitymulti-modal therapymulti-modal treatmentnovelnuclear disasternuclear eventnuclear incidentpulmonary damagepulmonary injurypulmonary tissue damagepulmonary tissue injuryradiation disasterradiation effectradiation eventradiation incidentradiation mitigatorradiation poisoningradiological accidentradiological disasterradiological eventradiological incidentradiological mitigatorradiomitigatorrenalrenal damageresponsestooltissue injurytraditional dosagetraditional dosing♀♂
Description preview
MERIE PROJECT 1: SUMMARY/ABSTRACT
Drugs are being developed to help people survive the effects of radiation from a large-scale event, such as
detonation of an improvised nuclear device (IND). While several agents are already approved to treat
hematopoietic acute radiation syndrome (H-ARS), which occurs at the lowest lethal radiation dose, there…
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