grant
Mining the microbiome for immunomodulatory microproteins
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 1 May 2025Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY2026AcuteAddressAnimalsAssayBacteriaBenchmarkingBest Practice AnalysisBioassayBiochemicalBiological AssayBiologyCRISPR editing screenCRISPR screenCRISPR-based screenCRISPR/Cas9 screenCancersCell BodyCell Communication and SignalingCell SignalingCellsCheckpoint inhibitorChemicalsCollaborationsDataElementsEnvironmentExposure toFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGI microbiomeGene TranscriptionGenetic TranscriptionGenomicsHeterogeneityHigh Throughput AssayHumanHuman MicrobiomeImmuneImmune checkpoint inhibitorImmune mediated therapyImmune responseImmune systemImmunesImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologically Directed TherapyImmunologicsImmunomodulationImmunotherapyIndividualIntracellular Communication and SignalingK pneumoniaeK. pneumoniaeKineticsKlebsiella pneumoniaeLeftLeptotrichiaLibrariesLifeMacrophageMalignant CellMalignant NeoplasmsMalignant TumorMeasuresMiceMice MammalsMicrobeMicrobiologyMicrobiomicsMiningModern ManMolecularMurineMusMφOncologistPathway interactionsPeptide LibraryPeptide SynthesisPeptidesPositionPositioning AttributePropertyProtein DynamicsProteinsRNA ExpressionRNA SeqRNA sequencingRNAseqReceptor ProteinResearchSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSystemT-CellsT-LymphocyteTestingTranscriptionTranslational ResearchTranslational ScienceTumor-associated macrophagesWorkanti-cancer immunotherapyanticancer immunotherapybenchmarkbiological signal transductioncancer cellcancer immunologycancer immunotherapycell typeclustered regularly interspaced short palindromic repeats screencommensal bacteriacommensal bacterial speciescytokinedesigndesigningdigestive tract microbiomeenteric microbiomeflow cytophotometryfunctional genomicsgastrointestinal microbiomegut microbesgut microbial speciesgut microbiomegut-associated microbiomehigh throughput screeninghost microbe associationhost microbe relationshiphost responsehost-microbe interactionshost-microbial interactionshost-microorganism interactionshuman-associated microbiomeiPSiPSCiPSCsimmune check point inhibitorimmune modulationimmune regulationimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based cancer therapiesimmune-based therapiesimmune-based treatmentsimmuno therapyimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseimmunotherapy for cancerimmunotherapy of cancerinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinnovateinnovationinnovativeinsightintestinal biomeintestinal microbesintestinal microbiomemacromoleculemalignancymicrobes genomemicrobialmicrobial genomemicrobiomemicrobiome researchmicrobiome sciencemicrobiome studiesmultiomicsmultiple omicsneoplasm immunologyneoplasm/cancernovelpanomicspathwayphenomenological modelsphenomenologypre-clinical studypreclinical studyprotein expressionreceptorresponsescRNA sequencingscRNA-seqscreeningscreeningssingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsmall moleculethymus derived lymphocytetranscriptome sequencingtranscriptomic sequencingtranslation researchtranslational investigationtumortumor immunology
Description preview
PROJECT ABSTRACT
Cancer immunotherapy, when effective, is lifesaving. Unfortunately, 15-50% of individuals will not respond to
therapy; therefore, efforts to ‘flip the switch’ and turn these ‘non-responders’ into ‘responders’ are critical and
urgent. Encouragingly, phenomenological studies in humans and preclinical studies in mice have…
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