grant
MiMA: Mother-infant Metabolite-transporter Atlas
Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 17 Sept 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY20250-11 years oldAffectAssayAtlasesAutoregulationBindingBioassayBioinformaticsBiologic ModelsBiological AssayBiological ModelsBiologyBloodBlood - brain barrier anatomyBlood PlasmaBlood Reticuloendothelial SystemBlood-Brain BarrierBody TissuesBreastBreast MilkBreastmilkCell BodyCellsCells Placenta-TissueChemicalsChildChild DevelopmentChild YouthChildren (0-21)ClassificationCommunicationCommunitiesCompensationComplexDataDevelopmentDiseaseDisorderDrug or chemical Tissue DistributionDrugsEnsureFoodGWA studyGWASGenomeGestationHealthHemato-Encephalic BarrierHomeostasisHumanHuman MilkHuman Mother's MilkImmobilizationIndividualInfantInfant and Child DevelopmentInfrastructureKnowledgeLactationLigandsLinkLiquid substanceLiteratureMacromolecular StructureMammary Gland MilkMammary glandMapsMaternal BehaviorMeasurementMeasuresMedicationMembraneMetabolite InteractionMilkModel SystemModelingModern ManMolecularMolecular InteractionMolecular StructureMother's MilkMothersMovementNomenclatureNormal PlacentomaNursing infantNutrientOpiatesOpioidOrganOrganoidsPatternPersonal SatisfactionPharmaceutical PreparationsPhysiologicPhysiologicalPhysiological HomeostasisPhysiologyPlacentaPlacenta Embryonic TissuePlacentomePlasmaPlasma SerumPregnancyProcessProteinsProteomicsReagentRecreationResearchResearch ResourcesResourcesReticuloendothelial System, Serum, PlasmaRoleSamplingSpecificityStandardizationStructureSurface Plasmon ResonanceSystemSystematicsSystems IntegrationTissue DistributionTissuesUpdateVHHVHH antibodyValidationVariantVariationXenobioticsabused drugabused drugsanti-depressant agentanti-depressant drugsanti-depressantsanti-depressive agentsbiophysical approachesbiophysical methodologybiophysical methodsbiophysical techniquesbloodbrain barrierbody movementcamelid antibodycamelid based antibodycamelid derived antibodycamelid derived fragmentcamelid heavy chain only Abscamelid immunoglobulincamelid single chain antibodycamelid variable heavy chaindevelopmentaldiet supplementdietary supplementsdrug abuseddrug of abusedrug safetydrug/agentdrugs abuseddrugs of abuseexperimentexperimental researchexperimental studyexperimentsfetalfetal bloodfluidgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studygut to brain axisgut-brain axisgut-brain communicationgut-brain interactionsgut-brain relationshipgut-brain signalinghuman diseaseinnovateinnovationinnovativeinsightintegrated systemintimacyintimate behaviorkidsknock-downknockdownlactatinglactationalliquidmaternal milkmedication safetymembrane structuremetabolism measurementmetabolomemetabolomicsmetabonomemetabonomicsmonolayermultiomicsmultiple omicsnanobodiesnanobodynovelnursing mothersnutritional supplementorthopedic freezingpanomicspharmaceutical safetypost-natal periodpostnatal periodprecision medicineprecision nutritionprecision-based medicinepregnantsdAbsingle domain antibodiessmall moleculesocial rolestructural biologysynergismsystem integrationuptakevalidationsvariable heavy chain antibodywell-beingwellbeingwhole genome association analysiswhole genome association studyyoungster
Description preview
ABSTRACT/SUMMARY
The maternal-fetal/infant axis of transport represents one of, if not the highest duration and intimacy of
long-distance communication across multi-tissue barriers between two individuals. Transporters enable such
communication by controlling the uptake and distribution of metabolites across membranes, tissues, organs, and
even…
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