grant
Midlife circulating autoantibodies and the risk of Alzheimer’s disease in Women
Organization NEW YORK UNIVERSITY SCHOOL OF MEDICINELocation NEW YORK, UNITED STATESPosted 1 Jan 2026Deadline 30 Nov 2030
NIHUS FederalResearch GrantFY202665 and older65 or older65 years of age and older65 years of age or more65 years of age or older65+ years65+ years oldAD biological markerAD biomarkerAD dementiaAD modelAD related biomarkerAD riskAD risk factorAccountingActive Follow-upAddressAgeAge YearsAged 65 and OverAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's biomarkerAlzheimer's disease biological markerAlzheimer's disease biomarkerAlzheimer's disease modelAlzheimer's disease related biomarkerAlzheimer's disease riskAlzheimer's related biomarkerAlzheimers DementiaAlzheimer’s biological markerAmentiaAmericanAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid Protein A4Amyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinAnimalsAntibodiesAntibody ResponseAntigensApoptoticAreaAssayAstroproteinAutoantibodiesAutoantigensAutoimmune DiseasesAutoimmune StatusAutoimmunityAutologous AntigensAβB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBioassayBiologic FactorBiological AssayBiological FactorsBiological MarkersBloodBlood Reticuloendothelial SystemBlood SampleBlood SerumBlood specimenBrainBrain Nervous SystemCNS Nervous SystemCalibrationCausalityCenters for Medicare and Medicaid ServicesCentral Nervous SystemChronic DiseaseChronic IllnessClassificationCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalDataDementiaDevelopmentDiabetes MellitusDiathesisDiseaseDisease susceptibilityDisorderDisturbance in cognitionDrugsELISAEncephalonEnrollmentEnzyme-Linked Immunosorbent AssayEpidemiologyEtiologyFemaleFemale HealthFundingGFA-ProteinGFAPGenital systemGlial Fibrillary Acid ProteinGlial Fibrillary Acidic ProteinGlial Intermediate Filament ProteinGonadal Steroid HormonesHealth Care Financing AdministrationHormonalHumanHypertensionImmune GlobulinsImmune systemImmunoglobulinsImmunomodulationImpaired cognitionIndividualInflammatory ResponseInterventionLate Onset Alzheimer DiseaseLate onset ADLife ExpectancyLife StyleLifestyleLightLinkLong-term cohort studyLongitudinal cohort studyMeasurementMeasuresMediatingMedicationModelingModern ManNerve DegenerationNested Case-Control StudyNeuraxisNeurofibrillary TanglesNeuron DegenerationObesityOlder PopulationPathogenicityPerformancePharmaceutical PreparationsPhasePhenotypePhotoradiationPilot ProjectsPlayPopulationPredispositionPreventionPrimary Senile Degenerative DementiaProspective StudiesProspective cohortProteomeProteomicsPublishingReproducibilityReproductive FactorsReproductive HistoryReproductive History EpidemiologyReproductive IssuesReproductive systemResearchResearch DesignRetrospective StudiesRiskRoleSample SizeSamplingSelf-AntigensSerumSex HormonesSex Steroid HormonesStudy TypeSusceptibilitySystematicsTechnologyTherapeutic InterventionUnited States Centers for Medicare and Medicaid ServicesUnited States Health Care Financing AdministrationVascular Hypertensive DiseaseVascular Hypertensive DisorderWomanWomen's Healtha beta peptideabetaabove age 65active followupadiposityafter age 65age 65 and greaterage 65 and olderage 65 or olderageage of 65 years onwardaged 65 and greateraged 65+aged ≥65agesalzheimer modelalzheimer riskamyloid betaamyloid-b proteinautoimmune antibodyautoimmune conditionautoimmune disorderautoimmunity diseaseautoreactive antibodybeta amyloid fibrilbio-markersbiologic markerbiomarkerbiomarker in ADbiomarker in Alzheimer'sbiomarker in Alzheimer's diseaseblood-based biomarkerblood-based markercase controlcase-controlledcausationchronic disorderco-morbidco-morbiditycognitive dysfunctioncognitive losscohortcomorbiditycorpulencedemographicsdevelopmentaldiabetesdisease causationdrug/agentenrollenzyme linked immunoassayepidemiologicepidemiologicalepidemiology research studyepidemiology studyepidemiology surveyfollow upfollow-upfollowed upfollowupgonadal steroidshigh blood pressurehigh riskhuman old age (65+)hyperpiesiahyperpiesishypertensive diseasehypertensive disorderimmune modulationimmune regulationimmunogenimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimprovedinnovative technologiesinsightintervention therapylate in lifelate lifelate onset alzheimerliability to diseaselife-style factorlifestyle factorsmalemenmid lifemid-lifemiddle agemiddle agedmidlifeneural degenerationneural inflammationneurodegenerationneurodegenerativeneurofibrillary degenerationneurofibrillary lesionneurofibrillary pathologyneurofilamentneuroinflammationneuroinflammatoryneurological degenerationneuronal degenerationnew drug treatmentsnew drugsnew markernew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel biomarkernovel drug treatmentsnovel drugsnovel markernovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyolder groupsolder individualsolder personover 65 yearsp-taup-τpathogenpathogenic autoantibodiesphospho-tauphospho-τphosphorylated taupilot studypost-translational modification of tauposttranslational modification of taupre-clinicalpreclinicalpredictive biological markerpredictive biomarkerspredictive markerpredictive molecular biomarkerprimary degenerative dementiaprospectiveprospective research studyprospective surveyreproductiveretrospective research studyretrospective surveyrisk factor for developing Alzheimer'srisk factor in Alzheimer'srisk of developing Alzheimer'srisk stratificationself reactive antibodysenile dementia of the Alzheimer typesex steroidsocial rolesoluble amyloid precursor proteinspecific biomarkersstratify riskstudy designtangletau phosphorylationtau posttranslational modificationtau-1toolτ phosphorylation≥65 years♀♂
Description preview
SUMMARY
Nearly two-thirds of the 6.9 million Americans age 65 and older with Alzheimer’s disease (AD) are women.
Women are more prone to AD than men due to hormonal, reproductive, lifestyle, and other biological factors,
even when accounting for their longer life expectancy. Regardless of age, females tend to have more B cells
and higher…
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