grant
Midcareer Mentoring for Clinical Research in HIV/AIDS-related cryptococcal and TB meningitis
Organization UNIVERSITY OF MINNESOTALocation MINNEAPOLIS, UNITED STATESPosted 20 Aug 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY202521+ years oldAIDSAIDS Associated Opportunistic InfectionAIDS VirusAIDS opportunistic infectionsAIDS-Related Opportunistic InfectionsAIDS/HIVAccountingAcquired Immune DeficiencyAcquired Immune Deficiency SyndromeAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency SyndromeAcquired Immunodeficiency Syndrome VirusAdultAdult HumanAfricaAfrica South of the SaharaAgeAreaAssayAwardBioassayBiological AssayBiological MarkersBrain InflammationCNS infectionCOVID-19CV-19CaringCentral Nervous System InfectionsCentral Nervous System Infectious DiseaseCentral Nervous System Infectious DisorderCerebromeningitisCerebrumCessation of lifeClinicalClinical ResearchClinical StudyCommunicable DiseasesCoronavirus Infectious Disease 2019CountryCreativenessCryptococcal MeningitisCryptococcosisCryptococcusDeathDecentralizationDetectionDiagnosisDiagnosticDiseaseDisorderDoctor of PhilosophyEconomic IncomeEconomical IncomeEducational workshopElectrolytesEncephalitisEncephalomeningitisEnrollmentFacultyFire - disastersFiresFutureGoalsGuidelinesHIVHIV therapyHIV-Related Opportunistic InfectionsHIV/AIDSHospitalsHumanHuman Immunodeficiency VirusesImmuneImmune responseImmune systemImmunesImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsImmunosuppressionImmunosuppression EffectImmunosuppressive EffectIncomeInfectious DiseasesInfectious DisorderInternationalInternetIntracranial PressureInvestigatorsK24 MechanismK24 ProgramLAV-HTLV-IIILeadershipLiquid substanceLymphadenopathy-Associated VirusM tuberculosis infectionM. tb infectionM. tuberculosis infectionM.tb infectionM.tuberculosis infectionMTB infectionManuscriptsMedicalMedicineMeningeal TBMeningeal TuberculosisMeningitisMeningoencephalitisMentorsMentorshipMidcareer Investigator Award in Patient-Oriented ResearchMidcareer Investigator Award in Patient-Oriented Research (K24)Modern ManMonitorMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis infectionNational Institutes of HealthNatureNervous System DiseasesNervous System DisorderNeurocognitiveNeurologic DisordersNeurological DisordersNew AgentsNon-Polyadenylated RNAOrganismOut-patientsOutcomeOutpatientsPerfusionPersonsPh D studentPh D. studentPh. D. studentPh.D studentPh.D.Ph.D. studentPhDPhD studentPhD. studentPhase 2/3 Clinical TrialPhase 3 Clinical TrialsPhase II/III Clinical TrialPhase III Clinical TrialsPoliciesPopulationPreventionProductivityProspective cohortPublishingRNARNA Gene ProductsRandomization trialRegimenResearchResearch PersonnelResearch ProposalsResearchersRibonucleic AcidSeminalSiteSteroid CompoundSteroidsStudentsSub-Saharan AfricaSubarachnoid PressureSubsaharan AfricaSupportive TherapySupportive careTB infectionTB meningitisTestingTherapeutic FungicidesTorulaTorulosisTrainingTranslational ResearchTranslational ScienceTranslationsTrustTuberculosisTuberculosis MeningitisTuberculous MeningitisUgandaUnderrepresented Ethnic MinorityUnderrepresented MinorityUnited StatesUnited States National Institutes of HealthValidationVirus-HIVWWWWorkWorkshopadulthoodagedagesanti-fungalanti-fungal agentsanti-fungal druganti-microbialantimicrobialbio-markersbiobankbiologic markerbiomarkerbiorepositorybrain tissuecareercerebralclinical careclinical relevanceclinical trial protocolclinically relevantcohortcoronavirus disease 2019coronavirus disease-19coronavirus infectious disease-19creativitydisabilitydisseminated TBdisseminated tuberculosisdoctoral studentenrollfirefluidglobal gene expressionglobal transcription profilehealth economicshost responseimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprovedincomesinfection due to Mycobacterium tuberculosisinnovateinnovationinnovativeliquidliving systemmortalitymultidisciplinaryneglectneurological diseasenew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypatient oriented researchpatient oriented studyphase 3 trialphase III protocolphase III trialpreventpreventingprogramsprospectiverandomized trialrandomized, clinical trialsscRNA sequencingscRNA-seqscreeningscreeningssingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingskillsstandard of caretooltranscriptometranslationtranslation researchtranslational investigationtuberculosis infectiontuberculous spondyloarthropathyunder-representation of minoritiesunder-represented minorityunderrepresentation of minoritiesvalidationswebworld wide web
Description preview
Abstract
Globally, central nervous system (CNS) infections have one of the largest burdens of death and disability,
particularly among persons with weaken immune systems due to the extremes of age, immunosuppressive
medicines, or HIV. Cryptococcal meningitis causes 15-19% of AIDS-related deaths, and TB-meningitis is the
deadliest form of…
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