grant
Midbrain Signals for Differential Reinforcement Learning
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 22 Sept 2025Deadline 21 Sept 2029
NIHUS FederalResearch GrantFY20252-photonASDAcousticsAddressAmygdalaAmygdaloid BodyAmygdaloid NucleusAmygdaloid structureAnimalsAppetiteAssociation LearningAssociative LearningAuditoryAuditory LocalizationAutismAutistic DisorderAvesAvianBNOSBarn OwlsBehaviorBehavioralBirdsBrainBrain Nervous SystemBrain regionCNS plasticityCausalityCell BodyCell Communication and SignalingCell NucleusCell SignalingCellsCodeCoding SystemCognitionConsumptionCorpus StriatumCorpus striatum structureDataDesire for foodDiseaseDisorderEarly Infantile AutismEncephalonEsthesiaEtiologyFore-BrainForebrainFrustrationGlutamatesHabitsHeadImageImpairmentInfantile AutismInferior ColliculusInstrumental LearningIntracellular Communication and SignalingJointsKanner's SyndromeKnowledgeL-GlutamateLanguage DevelopmentLearningLesionLightLinkMammaliaMammalsMapsMeasuresMedial geniculate bodyMesencephalonMethodsMiceMice MammalsMid-brainMidbrainMidbrain structureModelingMurineMusNC-NOSNNOSNOS 1 proteinNOS type INOS1 proteinNerve CellsNerve Impulse TransmissionNerve TransmissionNerve UnitNeural CellNeural Constitutive Nitric Oxide SynthaseNeurocyteNeurologicNeurologicalNeuronal PlasticityNeuronal TransmissionNeuronsNitric Oxide Synthase Type INucleusOperant ConditioningOutcomePathway interactionsPavlovian conditioningPerceptual learningPerformancePhotoradiationPopulationPosterior Quadrigeminal BodyProsencephalonPsychological reinforcementPublishingReinforcementRewardsSchizophreniaSchizophrenic DisordersSensationSignal TransductionSignal Transduction SystemsSignalingSiteSocial InteractionSound LocalizationSpeech PerceptionStimulusStriate BodyStriatumSystemTechniquesTestingThalamic NucleiTransmissionVertebrate AnimalsVertebratesViralWorkacquiring language skillsadaptive learningamygdaloid nuclear complexassociative conditioningautism spectral disorderautism spectrum disorderautistic spectrum disorderaxon signalingaxon-glial signalingaxonal signalingbehavior studybehavioral studybiological signal transductionbrain nitric oxide synthasecausationcell typecentral nervous system plasticityclassical conditioningdeafnessdementia praecoxdisease causationexperienceglia signalingglial signalingglutamatergicimagingimaging in miceimaging studies for miceimaging studies in miceinsightinstrumental conditioninglanguage acquisitionlanguage learningmice imagingmolecular biomarkermolecular markermurine imagingnNOS enzymenerve signalingneural mechanismneural plasticityneural signalingneuromechanismneuronalneuronal NOSneuronal form of nitric oxide synthaseneuronal nitric oxide synthaseneuronal signalingneuroplasticneuroplasticityneurotransmissionnitric oxide synthase 1noveloptogeneticspathwayreinforcerresponseschizophrenicsoundstriataltransmission processtwo-photonvertebrata
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Project Summary/Abstract
Associative learning is a fundamental cornerstone of behavior and cognition, but the underlying neural
mechanisms remain poorly understood. In vertebrates, the inferior colliculus (IC) is a layered, midbrain hub
important for sound localization, speech perception, and a potential site of plasticity for associative auditory…
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