grant
Microscale Radionuclide S-values for αRPT
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 19 Sept 2023Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY20253-D3-D modeling3-Dimensional3D3D modelingAccessory SinusesAddressAlpha Particle EmitterAlpha Particle RadiationAlpha RadiationAnatomic ModelsAnatomic SitesAnatomic structuresAnatomical ModelsAnatomyBeta ParticleBeta RadiationBeta RaysBleedingBloodBlood Reticuloendothelial SystemBlood capillariesBody TissuesBone MarrowBone Marrow Reticuloendothelial SystemCancer RadiotherapyCancer TreatmentCell BodyCellsCharged Particles-Electrons RadiationChemoresistanceClinicalClinical TrialsDevelopmentDiseaseDisorderDisseminated Malignant NeoplasmDoseFamily suidaeFreezingFutureGenerationsGeometryGoalsHarvestHemorrhageHistologyHumanImageIndividualKidneyKidney Urinary SystemKupffer CellsLabelLaboratory miceLacrimal GlandsLacrimal gland structureLibrariesLinear Energy TransferLiverLobeLobuleLungLung Respiratory SystemMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMarrowMetastatic CancerMetastatic Malignant NeoplasmMethodologyMethodsMiceMice MammalsMicroanatomyMicroscopic AnatomyMiniature SwineMinipigsModelingModern ManMurineMusNasal SinusesNasal cavity/ParanasalNasal cavity/Paranasal sinusesNephronsNormal TissueNormal tissue morphologyOrganOrgan ModelParanasal SinusesPathologyPatientsPhotonsPigsPopulationPre-Clinical ModelPreclinical ModelsPredispositionPublishingRadiation BiologyRadiation DoseRadiation Dose UnitRadioactive IsotopesRadiobiologyRadioisotopesRadionuclidesRadiopharmaceutical CompoundRadiopharmaceuticalsRadioresistanceResearch SpecimenRiskRisk AssessmentSYS-TXSalivary GlandsSeriesSinusSiteSmall IntestinesSourceSpecimenStellate Sinusoidal MacrophageStructureSuidaeSusceptibilitySwineSystemic TherapyTestingTimeTissue ModelTissuesToxic effectToxicitiesTumor CellUncertaintyUriniferous TubeWorkX-ray microtomographyXray microtomographyabsorptionanti-cancer therapyblood losscancer radiation therapycancer therapycancer-directed therapycapillarychemoresistantchemotherapy resistancechemotherapy resistantcomputer imagingcustomized therapycustomized treatmentdevelopmentaldigital imagingdosimetrydoubteffective therapyeffective treatmenthepatic body systemhepatic organ systemhuman imagingimagingin vivoindividual patientindividualized medicineindividualized patient treatmentindividualized therapeutic strategyindividualized therapyindividualized treatmentinter-patient variabilityinterestinterpatient variabilitykidney cortexkidney cortical portionliver macrophagelobesmicro CTmicro computed tomographymicroCTmicrotomographymini pigmini-swineminiswineneoplastic cellnovelparticlepatient specific therapiespatient specific treatmentpig modelpiglet modelporcineporcine modelpreservationprogramsradiation resistanceradio resistanceradioactive drugsradiotherapeutic drugsrenalrenal cortexskeletalsmall bowelsoft tissuesuidswine modeltailored medical treatmenttailored therapytailored treatmenttargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentthree dimensionalthree-dimensional modelingtissue preparationtooltreatment planningtumorunique treatmentvalidation studiesα Particle Emitterα Particlesβ-Particleβ-Rays
Description preview
Abstract / Summary – Project 2
Radiopharmaceuticals labeled with alpha-particle emitters (RPT) uniquely satisfy various conditions for therapy
of cancer in its advanced stages. Alpha particles have high linear-energy transfer (~100 keV / m) and thus short
tissue ranges (~50-80 m). Resultantly, they can sterilize tumor cells with as few as 1-3…
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