grant
MicroRNA directed pathway discovery in allergy and asthma
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 1 Aug 2011Deadline 28 Feb 2029
NIHUS FederalResearch GrantFY20253' Untranslated Regions3'UTRAffectAirway DiseaseAllergicAllergic ReactionAllergic asthmaAllergic inflammationAllergyAntibody TherapyApproaches to preventionAssayAsthmaAutoimmune StatusAutoimmunityB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBinding SitesBioassayBiochemicalBioinformaticsBiological AssayBiological FunctionBiological ProcessBody TissuesBronchial AsthmaCRISPRCRISPR/Cas systemCell BodyCell FunctionCell PhysiologyCell ProcessCell-Mediated Lympholytic CellsCellsCellular FunctionCellular PhysiologyCellular ProcessChronicChronic DiseaseChronic IllnessClinicalClustered Regularly Interspaced Short Palindromic RepeatsCodeCoding SystemCombining SiteCommunicationCuesCytokine Signal TransductionCytokine SignalingCytolytic T-CellCytotoxic T CellCytotoxic T-LymphocytesD12S1644DNA mutationDataDissectionElectroporationEpithelial CellsExtrinsic asthmaFamilyFunctional RNAGWA studyGWASGene ExpressionGene TargetingGene TranscriptionGenesGeneticGenetic ChangeGenetic PredispositionGenetic Predisposition to DiseaseGenetic SusceptibilityGenetic TranscriptionGenetic defectGenetic mutationGenetic propensityGenetic studyHelper CellsHelper T-CellsHelper T-LymphocytesHelper-Inducer T-CellsHelper-Inducer T-LymphocyteHyperactivityIL-4-STATImmuneImmune ToleranceImmune infiltratesImmune reactionImmune responseImmunesImmunologic ToleranceIncidenceInducer CellsInducer T-LymphocytesInflammatoryInherited PredispositionInherited SusceptibilityLinkLungLung InflammationLung Respiratory SystemMALAT1MALAT1 geneMapsMediatingMessenger RNAMethodsMicroRNAsMolecularMutationNon-Polyadenylated RNANoncoding RNANontranslated RNANucleic Acid Regulator RegionsNucleic Acid Regulatory SequencesPathogenesisPathway interactionsPneumonitisPost-Transcriptional ControlPost-Transcriptional RegulationPredispositionPreventionPrevention approachProbabilityProcessPulmonary InflammationRNARNA ExpressionRNA Gene ProductsRNA SequencesRNA and protein interactionRNA deliveryRNA-Binding ProteinsRNA-Protein InteractionReactive SiteRegulationRegulatory ElementRegulatory RegionsRegulatory T-LymphocyteReporterResearchResolutionRespiratory EpitheliumRibonucleic AcidRoleSTAT6STAT6 geneSTAT6BSTAT6CSignal InductionSignal PathwaySiteStructure of respiratory epitheliumSubcellular ProcessSusceptibilitySymptomsT-Cell SubsetsT-CellsT-LymphocyteT-Lymphocyte SubsetsTechniquesTechnologyTestingTherapeuticTissuesTranscriptionTransgenic MiceTranslational InhibitionTranslational RepressionTregUntranslated RNAWorkaeroallergensairborn allergenairborne allergenairway epitheliumairway epithelium inflammationairway inflammationallergic airway epithelium inflammationallergic airway inflammationalleviate symptomameliorating symptomantibody based therapiesantibody treatmentantibody-based therapeuticsantibody-based treatmentatopic asthmabase editingcausal allelecausal genecausal mutationcausal variantcausative mutationcausative variantchronic disordercrosslinkcytokinedecrease symptomelectroporative deliveryexperimentexperimental researchexperimental studyexperimentsextrinsic allergic asthmafewer symptomsgene electrotransfergenetic etiologygenetic mechanism of diseasegenetic regulatory elementgenetic vulnerabilitygenetically predisposedgenome mutationgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studyglobal gene expressionglobal transcription profilehost responseimmune cell infiltrateimmune system responseimmune system toleranceimmune unresponsivenessimmunological paralysisimmunoreactionimmunoresponseimprovedinsightinterleukin-4 Statkiller T cellmRNAmetastasis-associated lung adenocarcinoma transcript 1miRNAnew approachesnext generationnoncodingnovelnovel approachesnovel strategiesnovel strategypathwaypost-transcriptional gene regulationposttranscriptionalpreventpreventingprogramsprotein expressionprotein functionprotein purificationreduce symptomsregulatory T-cellsrelieves symptomsresolutionsrespiratory inflammationrespiratory tract epitheliumrespiratory tract inflammationresponsesocial rolesuccesssymptom alleviationsymptom reductionsymptom reliefthymus derived lymphocytetooltranscriptomewhole genome association analysiswhole genome association study
Description preview
PROJECT SUMMARY
Asthma is a highly prevalent chronic inflammatory airway disease that is genetically and
mechanistically linked to allergy and dysregulated cytokine-mediated communication between the
airway epithelial barrier and tissue-infiltrating immune cells. Th2 responses, insufficiently checked by
Tregs, drive chronic allergic inflammation…
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