grant
Microglial-serotonin interactions in the developing brain.
NIHUS FederalResearch GrantFY202521+ years old5-HT5-Hydroxytryptamine5HTAbscissionAddressAdultAdult HumanAffectiveAnhedoniaApoptosisApoptosis PathwayAutomobile DrivingBathingBathsBehaviorBehavioralBrainBrain Nervous SystemBrain regionCausalityCell BodyCell Communication and SignalingCell Growth in NumberCell MultiplicationCell ProliferationCell SignalingCellsCells Placenta-TissueCellular ProliferationColorCommunication challengeCommunication difficultyDataDevelopmentDietDietary InterventionDifferences between sexesDiffers between sexesDiseaseDisorderDorsalEffector CellEmbryoEmbryonicEncephalonEndotoxinsEnteramineEnvironmentEtiologyExcisionExhibitsExpression SignatureExtirpationFemaleFiberFluorescenceGene Expression ProfileGestationGoalsHeterogeneityHigh Fat DietHippophaineHomolog of Drosophila TOLLHortega cellHyperphagiaImageImmuneImmune responseImmunesImmunologic ReceptorsImmunological ReceptorsIn SituInflammationInflammatoryIntracellular Communication and SignalingL-TryptophanLevotryptophanLifeLinkMaternal NutritionMaternal dietMeasurementMeasuresMental DepressionMental disordersMental health disordersMiceMice MammalsMicrogliaMurineMusNerve CellsNerve Impulse TransmissionNerve TransmissionNerve Transmitter SubstancesNerve UnitNeural CellNeural DevelopmentNeurocyteNeuronal TransmissionNeuronsNeurotransmittersNormal PlacentomaNucleus AccumbensNutrition InterventionsNutritional InterventionsOutcomeOvereatingPatternPhagocytesPhagocytic CellPhagocytosisPlacentaPlacenta Embryonic TissuePlacentomePopulationPredispositionPregnancyProgrammed Cell DeathPsychiatric DiseasePsychiatric DisorderReceptor ProteinRemovalResearchRewardsRoleSaccharoseSerotoninSex DifferencesSexual differencesShapesSignal TransductionSignal Transduction SystemsSignalingSliceStimulusSucroseSupplementationSurgical RemovalSusceptibilitySystemTLR4TLR4 geneTestingTimeToll HomologueTranslatingTryptophanWorkadulthoodamebocyteaxon signalingaxon-glial signalingaxonal signalingbehavior outcomebehavioral healthbehavioral outcomebiological signal transductionbrain shapecausationcomparing females and malescomparing women and menconditional knock-outconditional knockoutdensitydepressiondevelopmentaldiet interventiondietsdisease causationdorsal raphe nucleusdrivingfemales compared to malesfemales compared with malesfemales versus malesfemales vs. malesfetalfetal programmingfocus on malefocused on mengene expression patterngene expression signaturegitter cellglia signalingglial signalinghost responseimagingimmune receptorimmune system responseimmunoresponseinflammation in mothersmalemale focusedmale specificmale targetedmaternal inflammationmaternal nutrition during pregnancymental illnessmesogliamicroglial cellmicrogliocytemigrationmother inflammationmother nutritionnerve signalingneural circuitneural circuitryneural signalingneurocircuitryneurodevelopmentneuronalneuronal signalingneurotransmissionoffspringperivascular glial cellpolyphagiapreferencepreventpreventingpsychiatric illnesspsychological disorderreceptorresectionresponsesaturated dietary fatsaturated dietary lipidsaturated fatsaturated lipidscRNA sequencingscRNA-seqsexsex based differencessex-dependent differencessex-related differencessex-specific differencessingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle moleculesingle-cell RNA sequencingsocialsocial defectssocial deficitssocial disorderssocial dysfunctionsocial rolestressorsynaptic circuitsynaptic circuitrytargeted to mentoll-like receptor 4transcriptional profiletranscriptional signaturewomen compared to menwomen compared with menwomen versus menwomen vs. men♀♂
Description preview
Summary of Work
Decades of research have strongly linked disruptions in the serotonin (5HT) system to mental health disorders
such as depression, and social and communication difficulties. Despite this link a gap remains in understanding
the etiologies of many of these disorders. Beyond its role in neurotransmission, 5HT is a critical morphogenic…
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