grant
Microglial modulation of neurocircuits in HIV/cocaine comorbidity
Organization UNIVERSITY OF SOUTH CAROLINA AT COLUMBIALocation COLUMBIA, UNITED STATESPosted 1 Jun 2023Deadline 31 Oct 2028
NIHUS FederalResearch GrantFY2026AIDS VirusAbscissionAccelerationAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAcuteAddressAffectAnimalsArchitectureAssessment instrumentAssessment toolBehaviorBrainBrain Nervous SystemCell Culture TechniquesCellular MatrixChemical DependenceChoice BehaviorChronicClinicalCocaineCocaine AbuseCytoskeletal SystemCytoskeletonDAT dopamine transporterDendritic SpinesDopamineDrug AddictionDrug DependenceDrug DependencyDrug ExposureDrug abuseDrug usageDrugsDysfunctionDysmorphologyEncephalonEngineering / ArchitectureExcisionExecutive DysfunctionExecutive Function DeficitExecutive ImpairmentExhibitsExposure toExtirpationF-ActinFemaleFilamentous ActinFunctional disorderFutureGeneralized GrowthGenesGoalsGrowthHIVHIV 1 associated neurocognitive disorderHIV InfectionsHIV associated neurocognitive deficitHIV associated neurocognitive impairmentHIV associated neurological diseaseHIV associated neurological disorderHIV induced neurocognitive deficitHIV induced neurocognitive impairmentHIV interventionHIV neurocognitive impairmentHIV therapeuticHIV therapyHIV treatmentHIV viral infectionHIV virus infectionHIV-1HIV-1 associated neurocognitive deficitHIV-1 associated neurocognitive disorderHIV-1 associated neurocognitive impairmentHIV-1 infectionHIV-1 interventionHIV-1 therapeuticHIV-1 therapyHIV-1 treatmentHIV-IHIV-associated neurocognitive disorderHIV1HistoryHortega cellHuman Immunodeficiency Virus Type 1Human Immunodeficiency Virus therapyHuman Immunodeficiency Virus treatmentHuman Immunodeficiency Virus-1Human Immunodeficiency VirusesHuman immunodeficiency virus 1HydroxytyramineIQ DeficitIn VitroIn vivo analysisIndividualInfectionInfection by HIV-1Infection from HIV-1Infection of HIV-1KnowledgeLAV-HTLV-IIILymphadenopathy-Associated VirusMeasuresMedialMediatingMedicationMicrogliaMicrotubule-Associated ProteinsModelingMotivationNatural regenerationNerve CellsNerve UnitNeural CellNeurocognitiveNeurocognitive DeficitNeurocognitive Impairment in HIVNeurocognitive Impairment in HIV-1NeurocyteNeurologicNeurologicalNeuronsNucleus AccumbensOutcomePathologicPathologyPathway interactionsPatientsPharmaceutical PreparationsPhysiopathologyPlayPrefrontal CortexPyramidal neuronRecording of previous eventsRegenerationRemovalReportingResistanceRoleScanningSelf AdministeredSelf AdministrationSignal PathwaySpecific qualifier valueSpecifiedSpinal ColumnSpineStimulantSubstance Use DisorderSubstance of AbuseSurgical RemovalSynapsesSynapticSynaptic plasticitySystemTechniquesTestingTissue GrowthUpregulationVentral Tegmental AreaVertebral columnVirusVirus-HIVabuse of drugsabuses drugsantiretroviral therapyantiretroviral treatmentbackbonebiological sexbrain cellcell culturecell culturesclinical significanceclinically significantco-morbidco-morbiditycocaine exposurecocaine self-administrationcocaine-exposedcomorbiditydendrite spinedensitydesigndesigningdopamine systemdopamine transporterdrug usedrug/agentexecutive controlexecutive functionexposed to cocaineexposure to cocainefrontal cortexfrontal lobegitter cellhippocampal pyramidal neuronhistorieshuman immunodeficiency virus infectionimprovedin vivoin vivo evaluationin vivo testinginfected with HIVinfected with human immunodeficiency virusintelligence quotient deficitintracellular skeletonmalemesogliamicroglial cellmicrogliocyteneural mechanismneuro-AIDSneuro-HIVneuroAIDSneuroHIVneurocognitive declineneurocognitive impairmentneuromechanismneuronalneuropathologicneuropathologicalneuropathologynew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachontogenypathophysiologypathwayperivascular glial cellprogramspsychostimulantpsychostimulant abuseregenerateresectionresistantself-administer cocainesexsocial rolestimulant abusesubstance usesubstance use and disordersubstance usingsubstances of abusesuccesssynapsesynapse functionsynaptic functiontargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic targettreat HIVtreat Human Immunodeficiency Virusventral tegmentum♀♂
Description preview
Project Summary:
Despite the success of combination antiretroviral therapy (cART), a significant proportion of infected individuals
exhibiting neurocognitive decline, and a prior history of substance use disorder (SUD) may result in an
exacerbated rate of decline. Thus, prior drug history may be clinically significant in the treatment of…
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