grant
Microbiota Metallophores: Probing Interactions and Nutrient Dynamics of the Human Gut
Organization UNIVERSITY OF DENVER (COLORADO SEMINARY)Location DENVER, UNITED STATESPosted 1 Aug 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025AffinityAnabolismAutoregulationB thetaiotaomicronB. thetaiotaomicronBacillus thetaiotaomicronBacteriaBacteroides thetaiotaomicronBindingBiologic ModelsBiologicalBiological MarkersBiological ModelsCellular Immune FunctionChemical StructureChemicalsCo-cultureCobaltCocultivationCocultureCoculture TechniquesCommunitiesComplexCopperCu elementDevelopmentE coliE. coliEnvironmentEscherichia coliFe elementGene ClusterGeneralized GrowthGeneticGoalsGrowthHomeostasisHumanHuman MicrobiomeIronKnowledgeLaboratoriesLinkMetalsMethodsMicrobeMicronutrientsMindModel SystemModern ManMolecular InteractionNatural ProductsNutrientNutritionOpportunistic InfectionsOrganismPhysiologicPhysiologicalPhysiological HomeostasisProbioticsProductionResearchResearch ResourcesResourcesRoleS thetaiotaomicronS. thetaiotaomicronSamplingSiderochromesSiderophoresSiteSpecificitySphaerocillus thetaiotaomicronStructureSystemTissue GrowthZincZn elementbio-markersbiologicbiologic markerbiomarkerbiosynthesisbowel inflammationchemical propertycommensal bacteriacommensal bacterial speciescommunity microbesdevelopmentalgut inflammationhuman datahuman florahuman microbial communitieshuman microbiotahuman microflorahuman-associated microbial communitieshuman-associated microbiomehuman-associated microbiotaimmune functionimprovedinflamed bowelinflamed gutinflamed intestineinsightintestinal inflammationliving systemmembermetagenome sequencingmetagenomic sequencingmicrobe communitymicrobialmicrobial communitymicrobial consortiamicrobial floramicrobial interactionmicrobiomemicrobiome interventionmicrobiome therapeuticsmicrobiome therapymicrobiome treatmentmicrobiome-based interventionmicrobiome-based therapeuticmicrobiome-based therapymicrobiome-based treatmentmicrobiotamicrofloramicroorganismmicroorganism communitymicroorganism interactionmultispecies consortiamutantnaturally occurring productontogenypolymicrobial communityprecision medicineprecision-based medicinepreferencesmall moleculesocial roleuptakeyersiniabactin
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Project Summary/Abstract
A healthy human microbiome is intrinsically linked to vital physiological aspects such as development, immune
function, and nutrition. The composition and function of the human microbiota is significantly influenced by
access to key metal micronutrients including iron, copper, zinc, and cobalt. Although mechanisms of…
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