grant
Microbiota mechanisms promoting Clostridioides difficile colon persistence
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 1 Nov 2025Deadline 31 Oct 2028
NIHUS FederalResearch GrantFY20252,3,7,8-Tetrachlorodibenzo-p-dioxin Receptors3-indolylacetic acidAH ReceptorsAcademiaAddressAdvisory CommitteesAffectAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAntibiotic AgentsAntibiotic DrugsAntibiotic TherapyAntibiotic TreatmentAntibioticsAryl Hydrocarbon ReceptorBiological MarkersC diffC difficileC. diffC. difficileCell BodyCellsCessation of lifeClinicalClostridioides difficileClostridium difficileColonColonic DiseasesColonic inflammationCommunitiesCulture MediaDataDeathDevelopmentDiarrheaDioxin ReceptorsDiseaseDisease OutcomeDisorderE coliE. coliEnvironmentEnzyme GeneEnzymesEscherichia coliFecesGI microbiotaGastrointestinal microbiotaGeneralized GrowthGerm-FreeGoalsGrowthHealth Care SystemsHigh Throughput AssayHistopathologyIES cpdImmuneImmune RegulatorsImmune responseImmune systemImmunesImmunomodulationImmunomodulatorsImmunosuppressionImmunosuppression EffectImmunosuppressive EffectInfectionInfection ControlInvestigationK pneumoniaeK. pneumoniaeKlebsiella pneumoniaeLibrariesLigandsLiquid ChromatographyLiteratureMacrophageMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMethodsMiceMice MammalsMicrobeMiscellaneous AntibioticModelingMolecularMorbidityMorbidity - disease rateMucosaMucosal Immune ResponsesMucosal TissueMucous MembraneMurineMusMφNuclear TranslocatorOralPathogenesisPathway interactionsPatientsPhenotypePolyaromatic Hydrocarbon ReceptorsPopulationPostdocPostdoctoral FellowPreventivePrimary InfectionProductionProteobacteriaPublic HealthPublishingPurple BacteriaRecurrenceRecurrentReportingResearchResearch AssociateResolutionRiskRisk FactorsRodSystemTCDD ReceptorsTask ForcesTestingTissue GrowthToxinUnited StatesUpregulationVirulenceWorkadvisory teambacterial communitybacterial disease treatmentbacterial infectious disease treatmentbeta-indoleacetic acidbio-markersbiologic markerbiomarkerbiomarker identificationcareerclassroom environmentcollege atmospherecollegial atmospherecollegiate atmospherecolon disordercolon microbescolon microbial communitycolon microbiomecolon microbiotacolonic microbiomecolonic microbiotacolonization resistancedevelopmentaleducation atmosphereeducational atmosphereeducational environmententeral pathogenenteric microbial communityenteric microbiotaenteric pathogenenteropathogengastrointestinal microbial floragrowth mediagut communitygut floragut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiotagut microbioticgut microflorahigh throughput screeninghost responseidentification of biomarkersidentification of new biomarkersimmune modulationimmune modulatorsimmune regulationimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmunologic reactivity controlimmunomodulatoryimmunomodulatory moleculesimmunoregulationimmunoregulatorimmunoregulatoryimmunoregulatory moleculesimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive responsein vivoindole acetic acidindole-3-acetic acidindoleacetic acidindolyl-3-acetic acidinfection recurrenceinflamed colonintellectual atmosphereintestinal floraintestinal microbiotaintestinal microfloraintestinal pathogenintestinal tract microfloraintestine pathogenlearning atmospherelearning environmentmarker identificationmetabolism measurementmetabolomicsmetabonomicsmicrobialmicrobial consortiamicrobial floramicrobial signaturemicrobiomemicrobiome componentsmicrobiome membersmicrobiotamicrofloramortalitymouse modelmultispecies consortiamurine modelmutantontogenypathogenpathwaypost-docpost-doctoralpost-doctoral traineepreventpreventingrecurrent infectionrecurring infectionresearch associatesresolutionsschool atmosphereschool climatesmall moleculestandard of carestooltraining atmosphereuniversity atmosphere
Description preview
Project Summary
Clostridiodes difficile is an opportunistic enteric pathogen which can cause critical and even fatal colonic disease.
Of the nearly 500,000 reported Clostridioides difficile infection (CDI) cases annually, a particularly unique
challenge facing clinicians is the striking level of recurrence of C. difficile disease (rCDI) following…
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