grant
Microbiome-driven immune changes and growth stunting in HIV-exposed uninfected children
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 11 May 2023Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY20260-11 years old0-4 weeks old5 year old5 years of age7S Gamma GlobulinAIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusActive Follow-upAddressAntibodiesAntibody ResponseAutoregulationB blood cellsB cellB cellsB-Cell SubsetsB-CellsB-Lymphocyte SubsetsB-LymphocytesB-cellBiologicalBirthBloodBlood PlasmaBlood Reticuloendothelial SystemBlood SerumBlood monocyteBreast FeedingBreast MilkBreastmilkCaringCells Placenta-TissueCharacteristicsChildChild HealthChild YouthChildhoodChildren (0-21)ClinicalCommunicable DiseasesCommunicationDataDefectDevelopmentDiarrheaDietEarly InterventionEarly identificationEnrollmentEnteralEntericEnvironmental ExposureEpidemiologyFc ReceptorFecesFoodFunctional MetagenomicsGI microbiomeGeneralized GrowthGestationGoalsGrowthHIVHIV disease statusHIV infection statusHIV serostatusHIV statusHIV1 infection statusHIV1 statusHealthHomeostasisHuman Immunodeficiency VirusesHuman MilkHuman Mother's MilkIgAIgGImmuneImmune responseImmune systemImmunesImmunityImmunoglobulin AImmunoglobulin GImmunologyInfectionInfectious DiseasesInfectious DisorderInflammatoryInfrastructureInnate Immune ResponseInvestigatorsLAV-HTLV-IIILaboratoriesLinkLong-term cohortLongitudinal cohortLymphadenopathy-Associated VirusMammary Gland MilkMarrow monocyteMaternal ImmunityMaternally-Acquired ImmunityMeasuresMetadataMetagenomicsMicrobeMorbidityMother's MilkMothersNational Institutes of HealthNeonatalNewborn InfantNewbornsNormal PlacentomaNutritionNutritional statusOrganismOutcomeParturitionPathogenicityPathway interactionsPhysiological HomeostasisPlacentaPlacenta Embryonic TissuePlacentomePlasmaPlasma SerumPlayPneumoniaPredispositionPregnancyPregnant WomenProteobacteriaPublic HealthPurple BacteriaReceptor ProteinRecurrenceRecurrentReportingResearchResearch PersonnelResearchersResolutionReticuloendothelial System, Serum, PlasmaRiskSamplingSerologySerumShapesShort-Chain Fatty AcidsSourceSusceptibilitySystemT-CellsT-LymphocyteTimeTissue GrowthUgandaUmbilical CordUmbilical cord structureUnited States National Institutes of HealthVaccinationViralVirulenceVirus-HIVVolatile Fatty AcidsWorkactive followupage 5age 5 yearsanti-microbialantibody receptorantibody transferantimicrobialantiretroviral therapyantiretroviral treatmentbiobankbiologicbiorepositoryburden of diseaseburden of illnessco-morbidco-morbiditycohortcomorbiditydata pipelinedevelopmentaldiarrheal diseasediarrheal illnessdietsdigestive tract microbiomedisease burdendisease modeldisorder modelenrollenteric microbiomeepidemiologicepidemiologicalexpectant motherexpectant womenexpecting motherexpecting womenexposure to environmental agentsexposure to environmental factorsexposure to environmental stimuliexposure to environmental substancesfecal samplefive year oldfive years of agefollow upfollow-upfollowed upfollowupgastrointestinal microbiomegut microbiomegut microbiome of infantgut-associated microbiomehigh riskhost responseimmune system responseimmunization strategyimmunoresponseimprovedimproved outcomeindividuals who are pregnantinfant gut microbiomeinfection recurrenceinnovateinnovationinnovativeintestinal biomeintestinal microbiomekidsliving systemmaternal milkmeta datametabolism measurementmetabolomicsmetabonomicsmicrobialmicrobiomemicrobiome community compositionmicrobiome compositionmicrobiome interventionmicrobiome species compositionmicrobiome structuremicrobiome therapeuticsmicrobiome therapymicrobiome treatmentmicrobiome-based interventionmicrobiome-based therapeuticmicrobiome-based therapymicrobiome-based treatmentmonocytemortalityneonate gut microbiomenewborn childnewborn childrennewborn gut microbiomenovelontogenypathobiontpathogenpathwaypediatricpeerpeople who are pregnantpoor health outcomepregnant femalespregnant motherspregnant peoplepregnant populationsprospectivereceptorreceptor bindingreceptor boundrecurrent infectionrecurring infectionreduced health outcomeresolutionsspecies differencestoolstool samplestool specimenthose who are pregnantthymus derived lymphocytevaccination strategyvaccine responsevaccine responsivenessvaccine strategyvaccine-induced responsewomen who are pregnantworse health outcomeyoungster
Description preview
Despite increasing access to antiretroviral therapy (ART) in pregnancy, the >1 million children born annually to pregnant women with HIV (PHIV) who are HIV-exposed but uninfected (HEU) remain at >2-fold higher risk of growth stunting and infectious morbidity than HIV-unexposed children. Though the origins of adverse HEU child health outcomes are…
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