grant
Microbial-based platform for assessing organ damage in alcohol use disorders (AUD)
Organization UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTONLocation HOUSTON, UNITED STATESPosted 15 Sept 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY2025AccountingAdoptedAdoptionAffectAgeAlcohol Chemical ClassAlcohol DrinkingAlcohol consumptionAlcoholsAnimal SourcesAutoregulationBiological MarkersBody TissuesClinicalColon CancerColon CarcinomaConsensusDataData SetDepositDepositionDiseaseDisorderDysfunctionEtOH drinkingEtOH useFecesFunctional MetagenomicsFunctional disorderFutureGI microbiotaGastrointestinal microbiotaGenderGeographic AreaGeographic LocationsGeographic RegionGeographical LocationGut Epithelial PermeabilityGut HyperpermeabilityGut permeabilityHealthHigh-Throughput Nucleotide SequencingHigh-Throughput SequencingHomeostasisHumanImmuneImmune responseImmunesIndividualInterventionIntestinalIntestinal Epithelial PermeabilityIntestinal HyperpermeabilityIntestinal LeakageIntestinal permeabilityIntestinesKnowledgeLarge IntestineLeaky GutLinkLiverLong-term cohortLongitudinal cohortMapsMetabolic PathwayMetagenomicsMiceMice MammalsMicrobeMicrobiomicsModern ManMucosaMucosal TissueMucous MembraneMurineMusOn-Line SystemsOnline SystemsOrganOutcomePancreasPancreaticParticipantPathway interactionsPerformancePhenotypePhysiological HomeostasisPhysiopathologyPlayPopulationPopulation HeterogeneityRNA SeqRNA sequencingRNAseqResearchResidualResidual stateRisk AssessmentRoleSamplingSingle-Nucleus SequencingTestingTexasTimeTissuesUpdateagesalcohol effectalcohol exposedalcohol exposurealcohol ingestionalcohol intakealcohol product usealcohol related researchalcohol researchalcohol responsealcohol usealcohol use disorderalcoholic beverage consumptionalcoholic drink intakebio-markersbiologic markerbiomarkerbonebowelcancer in the coloncohortdata diversitydata harmonizationdiverse datadiverse populationsdysbacteriosisdysbiosisdysbioticenteric microbial communityenteric microbiotaethanol consumptionethanol drinkingethanol effectethanol exposedethanol exposureethanol ingestionethanol intakeethanol product useethanol researchethanol responseethanol useethanol use disorderexposed to alcoholexposed to ethanolexposure to alcoholexposure to ethanolgastrointestinal microbial florageographic sitegut communitygut dysbiosisgut floragut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiotagut microbioticgut microfloraharmonized datahepatic body systemhepatic organ systemheterogeneous populationhigh riskhigh risk grouphigh risk individualhigh risk peoplehigh risk populationhost microbe associationhost microbe relationshiphost microbiomehost microbiotahost microflorahost responsehost-microbe interactionshost-microbial interactionshost-microorganism interactionsimmune system responseimmunoresponseimprovedinjury to organsinsightintestinal barrierintestinal floraintestinal microbiotaintestinal microfloraintestinal mucosal barrierintestinal tract microfloraknowledgebaselarge bowelmachine learned algorithmmachine learning algorithmmachine learning based algorithmmetabolism measurementmetabolomicsmetabonomicsmicrobialmicrobial consortiamicrobial floramicrobial imbalancemicrobial signaturemicrobiomemicrobiome researchmicrobiome sciencemicrobiome studiesmicrobiotamicrobiota patternsmicrobiota profilesmicrobiota signaturemicrofloramultispecies consortiaonline computerorgan injurypathophysiologypathwaypersonalized health interventionpersonalized interventionpopulation basedpopulation diversityprecision interventionsresident microbesresident microfloraresponseresponse to alcoholresponse to ethanolsNuc-Seqsample archivesingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqsnRNA sequencingsnRNA-seqsocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsstooltherapeutic targettranscriptome sequencingtranscriptomic sequencingvalidation studiesweb based
Description preview
Alcohol consumption is linked to various local and systemic organ damages. Research, including our own,
indicates that alterations in the gut microbiota play a significant role in alcohol's effects. Alcohol-induced
dysbiosis often leads to intestinal barrier dysfunction, worsening alcohol-related organ injuries. Interventions
targeting the…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click