grant
METTL3 in regulation of the aging process
Organization BROWN UNIVERSITYLocation PROVIDENCE, UNITED STATESPosted 1 Aug 2023Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2025AddressAdeno-Associated VirusesAdoptedAffectAgingAnimal ModelAnimal Models and Related StudiesAtrophicAtrophyAutoregulationBindingBinding ProteinsBiologic ModelsBiologicalBiological ModelsCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellular FunctionCellular PhysiologyCellular ProcessComplexDataDependoparvovirusDependovirusDeteriorationDysfunctionEC 2.1.1EngineeringEnzyme GeneEnzymesEquilibriumEventExercise ToleranceFunctional disorderGene ExpressionGene Expression ProcessGene TranscriptionGeneralized GrowthGenesGeneticGenetic TranscriptionGrowthHealthHomeostasisHypertrophyIntracellular Communication and SignalingKO miceKnock-out MiceKnockout MiceLifeLigand Binding ProteinLigand Binding Protein GeneMaintenanceMediatingMediatorMessenger RNAMetabolicMetabolic Protein DegradationMethylationMethyltransferaseMiceMice MammalsModel SystemModelingModificationMolecularMolecular InteractionMorbidityMorbidity - disease rateMovementMurineMusMuscleMuscle AtrophyMuscle TissueMuscle functionMuscular AtrophyNon-Polyadenylated RNANull MouseOrganPathologicPathway interactionsPhenotypePhysiological HomeostasisPhysiopathologyPost-Transcriptional ControlPost-Transcriptional RegulationProcessProtein BindingProtein BiosynthesisProtein TurnoverProteomeQOLQuality of lifeRNARNA ExpressionRNA Gene ProductsRNA methylationRNA-Binding ProteinsRegulationRegulatory Protein DegradationRibonucleic AcidRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRibosomesRoleSignal TransductionSignal Transduction SystemsSignalingSkeletal MuscleStimulusSubcellular ProcessTestingTherapeuticTimeTissue GrowthTranscriptionTranscriptional ControlTranscriptional RegulationTranslatingTranslationsTropismVoluntary Muscleadeno associated virus groupage related pathwaysage reversalaged miceaged mouseaged muscleaging associatedaging associated mechanismaging mechanismaging of muscleaging pathwayaging processaging relatedaging related mechanismaging related pathwaysaging reversalalleviate age relatedalleviate agingameliorating agingbalancebalance functionbiologicbiological mechanism of agebiological pathways of agebiological signal transductionbody movementbound proteincell agecellular ageclinical relevanceclinically relevantcounter age relatedcounter agingcounteract age relatedcounteract agingelderly miceexperimentexperimental researchexperimental studyexperimentsgain of functionhealthy aginghealthy human agingin vivoinsightloss of functionmRNAmRNA Translationmechanism regulating agingmechanisms involved in agingmedically necessarymedically necessary caremethylasemodel of animalmortalitymouse modelmurine modelmuscle agingmuscle breakdownmuscle bulkmuscle degradationmuscle deteriorationmuscle formmuscle lossmuscle massmuscle wastingmuscularnew approachesnovelnovel approachesnovel strategiesnovel strategyold miceontogenyoverexpressoverexpressionpathophysiologypathwaypathway involved in agingpost-transcriptional gene regulationposttranscriptionalpreservationpreventpreventingprogramsprospectiveprotein degradationprotein synthesisreceptor expressionreverse agereverse agingreverse aging effectsreversible agingsarcopeniasarcopenicsocial roletooltranslationtransmethylasewasting
Description preview
PROJECT SUMMARY
Aging is a complex process where perturbation of multiple molecular pathways contributes to organ
deterioration and aging-related morbidity and mortality. One component of the aging process is severe
dysregulation of gene expression that contributes to changes in the proteome of aged cells, which can
compromise cell function.…
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