grant
Methods to accelerate protein structure determination by solution NMR
Organization NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY20252019 novel corona virus2019 novel coronavirus2019-nCoV3-D3-D print3-D printer3-Dimensional3D3D Print3D printer3D printing4-dimensionalAccelerationActive SitesAgreementAlgorithmsBindingC-terminalCOVID-19 virusCOVID19 virusCalcium-Dependent Activator ProteinCalcium-Dependent RegulatorCalmodulinCell BodyCellsChemicalsClosure by LigationCoV-2CoV2CollectionDataData AnalysesData AnalysisData BasesData SetDatabasesDepositDepositionEquilibriumEsteroproteasesFour-dimensionalGoalsIonic StrengthsIsotopesLigationLiquid substanceMacromolecular StructureMagnetismMeasurementMeasuresMethodsModelingMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMolecular StructureMotionN-terminalNH2-terminalNMR SpectrometerNMR SpectroscopyPatternPeptidasesPeptide HydrolasesPhosphodiesterase Activating FactorPhosphodiesterase Protein ActivatorPopulationPredispositionPrintingProcessProtease GeneProteasesProtein DynamicsProteinasesProteinsProteolytic EnzymesResidualResidual stateResolutionRoentgen RaysSARS Coronavirus 2 ProteaseSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV-2 proteaseSARS-CoV2SARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2SamplingSavingsSchemeSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome related corona virus 2ShapesSodium ChlorideSpectroscopySpectrum AnalysesSpectrum AnalysisSpinal ColumnSpineStructureSusceptibilitySuspension substanceSuspensionsSystemTimeTubeVertebral columnVirusWuhan coronavirusX ray diffractionX ray diffraction analysisX-RadiationX-Ray RadiationX-rayXrayXray diffractionalpha helixaqueousbackbonebalancebalance functionconformationconformationalconformational stateconformationallyconformationscoronavirus disease 2019 viruscoronavirus disease-19 viruscostdata acquisitiondata acquisitionsdata basedata interpretationdynamic systemdynamical systemexperimentexperimental researchexperimental studyexperimentsfallsfluidhCoV19improvedliquidmagneticmaltose-binding proteinmonomermutantnCoV2novelnuclear magnetic resonance spectroscopypolypeptideprogramsprotein data bankprotein databankprotein structureprotein structuresproteins structureresolutionsrestraintsaltsevere acute respiratory syndrome coronavirus 2 proteasethree dimensionalthree dimensional printingα-helix
Description preview
Structural analysis of meta-stable proteins is challenging because measured parameters often reflect a population weighted average over the different states dynamically sampled by such systems.
New three- and four-dimensional NMR experiments have been developed that provide access to the structure and dynamics of systems that are large in…
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