grant
Methods for anterograde tracing of active circuits
Organization UNIVERSITY OF SOUTHERN CALIFORNIALocation Los Angeles, UNITED STATESPosted 4 Apr 2025Deadline 28 Feb 2030
NIHUS FederalResearch GrantFY2026AMPA ReceptorsAcetylcholineAddressAffinityAgingAnatomic SitesAnatomic structuresAnatomyAnesthesiaAnesthesia proceduresAntibodiesAntigenic DeterminantsAnxietyAxon TerminalsBehaviorBindingBinding DeterminantsBinding ProteinsBrainBrain Nervous SystemCell BodyCellsConnectionist ModelsDegenerative Neurologic DisordersDependenceDevelopmentDiseaseDisorderElectrophysiologyElectrophysiology (science)ElementsEncephalonEndowmentEpitopesEventFearFrightGABA ReceptorGeneticGoalsGrantLabelLearningLigand Binding ProteinLigand Binding Protein GeneMapsMediatingMemoryMethodsModernizationMolecular InteractionNerve CellsNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural Network ModelsNeural Network SimulationNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuromodulatorNeuronsNeurophysiology / ElectrophysiologyNeurosciencesPeptidesPerceptronsPerformancePresynaptic Nerve EndingsPresynaptic TerminalsPropertyProtein BindingProtein EngineeringProteinsRabies lyssavirusRabies virusReceptor ProteinSiteSpecific qualifier valueSpecifiedStructureSynapsesSynapticSynaptic BoutonsSynaptic CleftSynaptic TerminalsSynaptic VesiclesSynthetic antigen binderSystemTechniquesTestingTimeToxic effectToxicitiesTracerTransgenic AnimalsTransmissionVHHVHH antibodyVirusalpha-bungarotoxin binding sitesalpha-bungarotoxin receptoralpha7 nicotinic acetylcholine receptoralpha7nAChRantibody mimeticsantibody-like binderantibody-like moleculeantibody-like proteinantibody-like reagentartificial neural netartificial neural networkbound proteincamelid antibodycamelid based antibodycamelid derived antibodycamelid derived fragmentcamelid heavy chain only Abscamelid immunoglobulincamelid single chain antibodycamelid variable heavy chaincholinergiccholinergic neuroncognitive functioncomputational neural networkdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdesigndesigningdevelopmentalelectrophysiologicalexperimentexperimental researchexperimental studyexperimentsexposure to lightexposure to visible lightgamma-Aminobutyric Acid Receptorsgenetic protein engineeringin vivoinhibitory neuronlight exposurelight pollution exposurenanobodiesnanobodyneural circuitneural circuitryneurocircuitryneurodegenerative illnessneuronalnoveloptogeneticsperceptual stimulusphysicochemical phenomena related to the sensespost-synaptic nervespost-synaptic neuronspostsynapticpostsynaptic nervespostsynaptic neuronspre-synaptic nervepre-synaptic neuronspresynapticpresynaptic nervepresynaptic neuronsprotein designrational designreceptorrecombinaseresponsesdAbsensorsensory stimulussingle domain antibodiessynapsesynaptic circuitsynaptic circuitrysynthetic antigen binding reagentsynthetic neural networktooltransmission processvariable heavy chain antibodyα7 nicotinic acetylcholine receptorα7nAChR
Description preview
Project Summary
A central yet unrealized goal of modern neuroscience is to map all the neural circuits within the brain and the
changes that occur during development, learning, aging, and in disease states. Towards this end, we recently
developed a rationally designed method for anterograde transsynaptic tracing from excitatory presynaptic
neurons…
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