grant
Metalloenzyme Discovery and Pathway Engineering to Functionalizethe Inert C-H bonds of Amino Acids
Organization PRINCETON UNIVERSITYLocation Princeton, UNITED STATESPosted 1 Mar 2026Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY20252,5-Diaminopentanoic AcidActive SitesAddressAdoptionAlkaloidsAmino Acid SequenceAmino AcidsApplied ResearchApplied ScienceAreaAttentionBiochemistryBioinformaticsBiological ChemistryBiological FunctionBiological ProcessBiologyBypassCarbonCatalysisChemicalsChemistryComplexCytochrome P-450Cytochrome P-450 Enzyme SystemCytochrome P450Cytochrome P450 Family GeneDNA Molecular BiologyDerivationDerivation procedureDrug usageDrugsEngineeringEnzyme GeneEnzymesFamilyFerroprotoporphyrinGene ClusterGene ModifiedGenerationsGenesGenetic MarkersGenomeH-bondHemeHydrogen BondingIn VitroIndustrializationKineticsL-LysineLysineMedicationMetabolic PathwayMethodsMiningModificationMolecular BiologyNatural ProductsOrnithineOxidasesOxygenasesP450Pathway interactionsPenicillinsPeptide-based drugPeptidesPharmaceutical PreparationsPlayPositionPositioning AttributePrimary Protein StructureProcessProductionPropertyProtein EngineeringProtohemeReactionResearchRoleScientific Advances and AccomplishmentsStereoisomerStructureSynthesis ChemistrySynthetic ChemistrySystemTransition ElementsWorkaminoaciddesigndesigningdrug discoverydrug usedrug/agentferrohemefunctional groupgene biomarkergene expression biomarkergene markergene modificationgene signature biomarkergenetic biomarkergenetic protein engineeringgenetically modifiedhalogenationin vivometalloenzymemolecular recognitionnaturally occurring productnon-Nativenonnativepathwaypeptide drugpolyketidesprotein designprotein sequencescaffoldscaffoldingscientific accomplishmentsscientific advancesscreeningscreeningssmall moleculesocial rolestereochemistrysuccesstherapeutic peptidetransition metal
Description preview
Metalloenzymes serve in a myriad of critical biological processes. Notably, their ability to natively
functionalize inert C–H bonds with high regio- and stereoselectivity has garnered significant attention, as the
direct functionalization of chemical feedstock through C–H bond functionalization would serve as a streamlined
strategy for accessing…
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