grant
Metabolomic and genomic expansion of type 2 diabetes subtyping in multiethnic populations
Organization WAKE FOREST UNIVERSITY HEALTH SCIENCESLocation WINSTON-SALEM, UNITED STATESPosted 1 Sept 2024Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY202521+ years oldASCVDAdultAdult HumanAdult-Onset Diabetes MellitusAfrican AmericanAfro AmericanAfroamericanAgeAmericanAsianAssayAtherosclerosisAtherosclerosis Risk in CommunitiesAtherosclerotic Cardiovascular DiseaseBeta CellBioassayBiochemicalBiochemical MarkersBiochemical PathwayBiological AssayBiometricsBiometryBiostatisticsBlackBlack raceBlood SampleBlood specimenBody TissuesBrain Vascular DisordersCaringCausalityCell FunctionCell PhysiologyCell ProcessCellular FunctionCellular PhysiologyCellular ProcessCerebrovascular DiseaseCerebrovascular DisordersChronic Kidney FailureChronic Renal DiseaseChronic Renal FailureClassificationClinicalCollaborationsCollectionComplications of Diabetes MellitusComputing MethodologiesCoronary Artery Risk Development in Young AdultsCoronary Artery Risk Development in Young Adults StudyCoronary DiseaseCoronary heart diseaseCoupledDataData Coordinating CenterData Coordination CenterData ScienceDevelopmentDiabetes ComplicationsDiabetes MellitusDiabetes-Related ComplicationsDiabetic ComplicationsDiseaseDisease OutcomeDisease ProgressionDisorderDrug TherapyDysfunctionEnrollmentEpidemiologyEthnic GroupEthnic PeopleEthnic PopulationEthnic individualEthnicity PeopleEthnicity PopulationEtiologyFamily StudyFemaleFreezingFunctional disorderGeneticGenetic PredispositionGenetic Predisposition to DiseaseGenetic SusceptibilityGenetic propensityGenomicsGenotypeGoalsGroups at riskHCHS/SOL StudyHCHS/SOL cohortHealthHeartHeart failureHeterogeneityHispanicHispanic Community Health StudyHispanic Community Health Study/Study of LatinosIndividualInherited PredispositionInherited SusceptibilityInsulin CellInsulin ResistanceInsulin Secreting CellInsulin deficiencyInterventionIntracranial Vascular DiseasesIntracranial Vascular DisordersKetosis-Resistant Diabetes MellitusKnowledgeMaturity-Onset Diabetes MellitusMetabolic NetworksMethodologyMethodsModelingMulti-Ethnic Study of AtherosclerosisNIDDMNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusObesityOrganism-Level ProcessOrganismal ProcessPatientsPatternPeople at riskPersons at riskPharmacological TreatmentPharmacotherapyPhenotypePhysiologicPhysiologic ProcessesPhysiologicalPhysiological ProcessesPhysiologyPhysiopathologyPopulationPopulations at RiskPositionPositioning AttributePrediabetesPrediabetes syndromePrediabetic StatePreventative strategyPreventionPrevention strategyPreventive strategyProcessRaceRacesRandomized, Controlled TrialsReproducibilityResearchRetinal DiseasesRetinal DisorderRiskRunningSEARCH for Diabetes in YouthSlow-Onset Diabetes MellitusStable Diabetes MellitusStandardizationStatistical MethodsSubcategorySubcellular ProcessSubgroupSystematicsT2 DMT2DT2DMTestingTissuesType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesWorkadiposityadult onset diabetesadulthoodadverse consequenceadverse outcomeagesatheromatosisatherosclerotic diseaseatherosclerotic vascular diseasebrain vascular diseasebrain vascular dysfunctioncardiac failurecardiovascular disease riskcardiovascular disorder riskcausationcerebral vascular diseasecerebral vascular dysfunctioncerebrovascular dysfunctionchronic kidney diseaseclinical careclinical phenotypeclinical riskcohortcomputational methodologycomputational methodscomputer based methodcomputer methodscomputing methodcoronary disordercorpulencedata diversitydata integrationdevelopmentaldiabetesdisease causationdiverse datadrug interventiondrug treatmentenrollepidemiologicepidemiologicalethnic diversityethnic subgroupethnically diverseethnicity groupgenetic etiologygenetic mechanism of diseasegenetic vulnerabilitygenetically predisposedhealth dataimprovedinsulin resistantinsulin toleranceintracranial vascular dysfunctionketosis resistant diabeteslife style interventionlifestyle interventionmaturity onset diabetesmetabolism measurementmetabolomicsmetabonomicsmortalitymulti-ethnicmultidisciplinarymultiethnicmultiple data typesnovelpathophysiologypharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspre-diabetespre-diabeticprecision medicineprecision-based medicineprediabeticprospectiveracialracial backgroundracial originrandomized control trialresponseretina diseaseretina disorderretinopathyrisk minimizationsocial determinantssocial health determinantssocial influencesociodeterminantstatistic methodsstudy populationtraittreatment strategytype 2 DMtype II DMtype two diabetesβ-cellβ-cellsβCell♀
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Project Summary/Abstract
Type 2 diabetes (T2D) involves derangement in multiple tissues, yet the physiological drivers of disease will vary
and are difficult to discern for a given individual. This variability in T2D pathophysiology contributes to
heterogeneity in T2D complications and in which treatment strategy will offer optimum benefit.…
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