grant
Metabolic Resuscitation in Heart Failure.
Organization TEXAS A&M UNIVERSITY HEALTH SCIENCE CTRLocation COLLEGE STATION, UNITED STATESPosted 1 Jul 2024Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY20253-PyridinecarboxamideAddressAgeAnimal GeneticsAnimal ModelAnimal Models and Related StudiesAnimalsBackBiologicalBiological MarkersBlood PlasmaBody TissuesCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCardiacCardiac Muscle CellsCardiac MyocytesCardiocyteCas nuclease technologyCell BodyCellsClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCollaborationsConsumptionCyclicityDNA mutationDataDeath RateDehydratasesDiagnosticDorsumDown-RegulationDrainageDrainage procedureDysfunctionEFRACEjection FractionElectronsEnergy ExpenditureEnergy MetabolismEnsureEnzyme GeneEnzymesExhibitsFailureFunctional disorderGenerationsGenesGeneticGenetic ChangeGenetic defectGenetic mutationHeartHeart Muscle CellsHeart failureHeart myocyteHistologyHumanHydrasesHydrationHydration statusHydro-LyasesImpairmentIn VitroInvestigationInvestigatorsKO miceKnock-outKnock-out MiceKnockoutKnockout MiceLinear ModelsLinkLytotoxicityMediatingMetabolicMetabolic PathwayMiceMice MammalsMitochondriaModelingModern ManMorphologyMurineMusMuscle CellsMutationMyocardialMyocytesNADHNegative Beta ParticleNegatronsNiacinamideNicotinamideNicotinamidumNicotinic acid amideNicotylamideNon-Polyadenylated RNANucleotidesNull MouseOrphan DiseasePathogenesisPathogenicityPathologicPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPellagra-Preventing FactorPeriodicityPhenotypePhysiopathologyPlasmaPlasma SerumPreventionProductionRNARNA Gene ProductsRare DiseasesRare DisorderRegulationResearch PersonnelResearch ResourcesResearchersResourcesResuscitationReticuloendothelial System, Serum, PlasmaRhythmicityRibonucleic AcidRoleSignal PathwayStressSystemTechnologyTestingTherapeuticThinkingTissuesToxic effectToxicitiesTreatment FailureUrineVitamin B 3Vitamin B3Vitamin PPWorkagesbio-markersbiologicbiologic markerbiomarkercardiac failurecardiac functioncardiomyocytechemical reactionclinical relevanceclinically relevantcytotoxicitydeep sequencingepimerasefunction of the heartgenome mutationglobal gene expressionglobal transcription profileheart functionhiPSChuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellshuman subjectimprovedin vivoinduced human pluripotent stem cellsinnovateinnovationinnovativeknock-downknockdownmetabolism measurementmetabolomicsmetabonomicsmitochondrialmodel of animalmortality ratemortality ratiomutantnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachorphan disorderpathophysiologypatient oriented outcomespreservationpreventpreventingprogramsrepairrepairedsexsocial roletherapy failurethoughtstranscriptometranslational opportunitiestranslational potentialwasting
Description preview
PROJECT DESCRIPTION/ABSTRACT
The heart requires a constant supply of ATP to meet its high energy demands and maintain its contractile
function. The relationship between cardiac energy deficiency and heart failure has been extensively studied,
leading to various strategies to improve energy deficiency in heart failure. However, despite these…
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