grant
Metabolic Reprogramming in Experimental Deep Vein Thrombosis and Resolution
Organization UNIVERSITY OF IOWALocation IOWA CITY, UNITED STATESPosted 1 Aug 2025Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025AbscissionAccelerationAccessory SinusesAcuteAddressAffectAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAnticoagulant AgentsAnticoagulant ChemotherapyAnticoagulant DrugsAnticoagulant therapyAnticoagulantsAnticoagulationAntiplatelet AgentsAntiplatelet DrugsApo E ReceptorApoE ReceptorApolipoprotein E ReceptorApoptoticBlood NeutrophilBlood PlateletsBlood Polymorphonuclear NeutrophilBlood VesselsBlood leukocyteCathetersCell BodyCellsChronicCollagenCommon Rat StrainsComplicationCustomDeep FieldDeep Vein ThrombosisDeep-Venous ThrombosisDevelopmentDimensionsDimerizationDiseaseDisorderDistalExcisionExtirpationExtremitiesFemoral veinFibroblastsFibrosisGeneticHealthHumanImmunology procedureIn VitroInferior Vena CavaInferior vena cava structureInflammationInflammatoryInflammatory ResponseInjuryIsoenzymesIsozymesKnowledgeLDL-Receptor Related Protein 1LeukocytesLeukocytes Reticuloendothelial SystemLimb structureLimbsLow Density Lipoprotein Receptor-Related ProteinLow-Density-Lipoprotein Receptor-Related Protein-1MacrophageMarrow NeutrophilMarrow leukocyteMarrow plateletMetabolicMetabolic PathwayMiceMice MammalsMicrofluidic DeviceMicrofluidic Lab-On-A-ChipMicrofluidic MicrochipsModelingModern ManMolecularMotorMurineMusMutant Strains MiceMyographyMφNasal SinusesNasal cavity/ParanasalNasal cavity/Paranasal sinusesNatureNeutrophilic GranulocyteNeutrophilic LeukocyteNon-TrunkOralParanasal SinusesPathogenesisPathological ConstrictionPathway interactionsPatientsPhlebothrombosisPilot ProjectsPlatelet ActivationPlateletsPlayPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPost thrombotic syndromePost-phlebitic DiseasePostphlebitic DiseasePostphlebitic SyndromePostthrombotic syndromePreventionProductionProtein DimerizationPublishingPulmonary EmbolismPyruvate KinaseRatRats MammalsRattusRemovalReperfusion TherapyResearchResidualResidual stateResolutionRiskRoleSamplingSinusStenosisStentsSurgical RemovalTestingTherapeuticTherapeutic InterventionThrombectomyThrombocytesThrombosisThrombusVeinsVenousVenous ThrombosisVenous ulcer-leg syndromeWhite Blood CellsWhite CellWhole BloodWild Type Mousealpha-2-Macroglobulin Receptoralpha2-Macroglobulin Signaling Receptorblood thinnercell typecompression therapycustomsdeep field imagedeep field surveydevelopmentaldimereffective interventioneffective therapyeffective treatmentefficacious therapyefficacious treatmentextracellularhealth care burdenimmunologic assayimmunologic assay/testimprovedinjuriesinnovateinnovationinnovativeintervention therapymicrofluidic chipmouse mutantnanoneutrophilnew approachesnovelnovel approachesnovel strategiesnovel strategypathwaypharmacologicphosphoenol transphosphorylasephosphoenolpyruvate kinasepilot studypleiotropic effectpleiotropismpleiotropypost-phlebitic syndromepreventpreventingprogramsreperfusionresectionresolutionssocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicssuccesstargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentthromboinflammationthromboinflammatorythrombolysisthrombopoiesis inhibitorthrombotic diseasethrombotic disorderultrasoundvascularvenous thromboembolismwhite blood cellwhite blood corpusclewildtype mouse
Description preview
Project summary
Venous thromboembolism (VTE), encompassing deep vein thrombosis (DVT) and its major short-term
complication, pulmonary embolism (PE), represents a significant health issue in the US and worldwide. The
mainstay of current DVT treatment is oral anticoagulant therapy. It decreases the risk of DVT reoccurrence but,
unfortunately, does…
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