grant
Metabolic regulation of Neutrophil Extracellular Traps (NETs) in TBI
Organization HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCESLocation EAST LANSING, UNITED STATESPosted 1 Jun 2025Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY2025Acquired brain injuryAddressAntiinflammatory EffectAssayAttenuatedAutomobile DrivingBehavior assessmentBioassayBiochemicalBioenergeticsBiological AssayBlood NeutrophilBlood Polymorphonuclear NeutrophilBody TissuesBone MarrowBone Marrow Reticuloendothelial SystemBrainBrain DiseasesBrain DisordersBrain InjuriesBrain Nervous SystemBrain TraumaCerebral EdemaComprehensionDataDeath RateDoseEconomic BurdenEncephalonEncephalon DiseasesFemaleGene ModifiedGlycolysisGoalsHexose Monophosphate ShuntHistologicHistologicallyHumanImpairmentInflammationInflammatoryInflammatory ResponseInjuryIntermediary MetabolismIntracranial CNS DisordersIntracranial Central Nervous System DisordersInvestigationKO miceKnock-out MiceKnockout MiceKnowledgeMarrow NeutrophilMediatingMetabolicMetabolic ProcessesMetabolismMiceMice MammalsModern ManMurineMusNerve CellsNerve UnitNeural CellNeurocyteNeurologic DeficitNeurological disabilityNeuronal InjuryNeuronsNeutrophil ActivationNeutrophilic GranulocyteNeutrophilic LeukocyteNull MouseOutcomePathway interactionsPentose Phosphate PathwayPentose Phosphate ShuntPentose ShuntPentosephosphate PathwayPentosephosphate ShuntPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsProcessPublic HealthRegulationResearchResolutionRoleSchemeSeveritiesSourceTBI therapyTBI treatmentTestingTherapeuticTissuesTransgenic MiceTraumatic Brain InjuryWorkanti-inflammatory effectattenuateattenuatesbehavioral assessmentbehavioral impairmentbrain damagebrain tissuebrain-injureddetermine efficacydisabilitydrivingeffective therapyeffective treatmentefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationevaluate efficacyexamine efficacyextracellularfunctional outcomesgene modificationgenetically modifiedimpaired behaviorimprovedinjuriesinnovateinnovationinnovativeinsightmalemetabolic ratemortality ratemortality ratiomouse modelmurine modelneural inflammationneurobehavioralneuroinflammationneuroinflammatoryneuron injuryneuronalneuropathologicneuropathologicalneuropathologyneuroprotectionneuroprotectiveneutrophilnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathwaypharmacologicpre-clinicalpre-clinical studypreclinicalpreclinical studyresolutionsrestorationsham surgerysocial rolesocio-economicsocio-economicallysocioeconomicallysocioeconomicstargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttraumatic brain damagetraumatic brain injury therapytraumatic brain injury treatment♀♂
Description preview
Abstract: Traumatic brain injury (TBI) is a significant global public health issue, leading to high mortality
rates, disabilities, and substantial socioeconomic burdens. TBI results in the loss of AMPKα activity, disruption
in regional metabolism, persistent changes in metabolic rates and energy utilization, and elevated glycolysis
which enhance…
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