grant
Metabolic regulation of fibrosis through STAT3 signaling
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 1 May 2026Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2026APRF proteinAcute-Phase Response FactorAdult-Onset Diabetes MellitusAffectAgonistAll-Trans-RetinolAnti-Infective vitaminAnti-diabetic AgentsAnti-diabetic DrugsAntixerophthalmic vitaminAutocrine CommunicationAutocrine SignalingAutocrine SystemsAutomobile DrivingAutoregulationAxerophtholAxerophtholumB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2BCDFBSF-2BSF2Biochemical ReactionBiosterolBlood GlucoseBlood SugarBone-Derived Transforming Growth FactorCell Communication and SignalingCell LineCell SignalingCell-Extracellular MatrixCellLineClassificationCollagenCytokine ActivationD-GlucoseDataDepositDepositionDevelopmentDextroseDisease ProgressionDrug PrescribingDrug PrescriptionsDrugsECMEffectivenessEnzymatic ReactionExtracellular MatrixFDA approvedFatsFatty acid glycerol estersFeedbackFibroblastsFibrosisGlucoseGlycolysisGoalsGrowth AgentsGrowth FactorGrowth SubstancesHPGFHepatic CellsHepatic DisorderHepatic Parenchymal CellHepatic Stellate CellHepatocyteHepatocyte-Stimulating FactorHomeostasisHumanHybridoma Growth FactorIFN-beta 2IFNB2IL-6IL6 ProteinIL6-response factorInflammationInterleukin-6Intermediary MetabolismIntracellular Communication and SignalingIto CellJAK kinaseJanus kinaseKetosis-Resistant Diabetes MellitusLIF-response factorLard-FactorLeptinLiverLiver CellsLiver FibrosisLiver diseasesMGI-2Maturity-Onset Diabetes MellitusMediatingMedicationMetabolicMetabolic PathwayMetabolic ProcessesMetabolic dysfunctionMetabolismMilk Growth FactorModern ManMyeloid Differentiation-Inducing ProteinMyofibroblastNADHNIDDMNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusOb Gene ProductOb ProteinObese Gene ProductObese ProteinOleovitamin AOphthalaminOutcomeParacrine CommunicationParacrine SignalingPathway interactionsPharmaceutical AgentPharmaceutical PreparationsPharmaceuticalsPharmacologic SubstancePharmacological SubstancePhysiological HomeostasisPlasmacytoma Growth FactorPlatelet Transforming Growth FactorPlayPopulationProteins Growth FactorsPyruvateRegimenRegulationResearchRoleSTAT proteinSeriesSignal PathwaySignal Transducer and Activator of TranscriptionSignal Transducer and Activator of Transcription 3Signal TransductionSignal Transduction SystemsSignalingSlow-Onset Diabetes MellitusStable Diabetes MellitusStat3 proteinSteatohepatitisStrains Cell LinesSystematicsT2 DMT2DT2DMTGF BTGF-betaTGF-βTGFbetaTGFβTestingTherapeuticTimeTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesVitamin A Alcoholadult onset diabetesanti-diabeticautocrinebiological signal transductioncell typecultured cell linecytokinedeprivationdevelopmentaldrivingdrug/agenteffective therapyeffective treatmentfibrotic liverglucagon-like peptide receptorglucose metabolismhepatic body systemhepatic diseasehepatic fibrosishepatic inflammationhepatic organ systemhepatopathyin vivoinflamed liverinjuredinsightinterferon beta 2ketosis resistant diabetesliver disorderliver inflammationmaturity onset diabetesmedication prescriptionmouse modelmurine modelnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyparacrinepathwaypharmaceuticalpre-clinicalpreclinicalprescribed medicationresponseretinolslow potentialsocial roletherapeutic agent developmenttherapeutic developmenttransdifferentiationtype 2 DMtype II DMtype two diabetes
Description preview
Project Summary
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common liver disease, affecting
approximately 30% of the world population. MASLD can result in an increase in inflammation in the liver and
can progress overtime to liver fibrosis, characterized by excess extracellular matrix deposition. A major
collagen…
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