grant
Metabolic Bone Disorders Unit
Organization NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCHLocation UNITED STATES
NIHUS FederalResearch GrantFY20250-11 years old21+ years old3'5'-cyclic ester of AMP65 and older65 or older65 years of age and older65 years of age or more65 years of age or older65+ years65+ years oldAdenosine Cyclic 3',5'-MonophosphateAdenosine Cyclic MonophosphateAdenosine, cyclic 3',5'-(hydrogen phosphate)AdultAdult HumanAffectAged 65 and OverAlbright SyndromeAlbright's syndromeAmericanAntibodiesBindingBiologic ModelsBiological ModelsBlindnessBloodBlood Reticuloendothelial SystemBone DiseasesCalciumCaringCell Growth in NumberCell MultiplicationCell ProliferationCellular ProliferationCessation of lifeChildChild WelfareChild YouthChildhoodChildren (0-21)ChronicChronic DiseaseChronic IllnessChronic disabilityClinicalComplexCosten's SyndromeCyclic AMPDataData AnalysesData AnalysisData SetDeathDevelopmentDiseaseDisorderDropoutDysfunctionEndocrineEndocrine DiseasesEndocrine Diseases and ManifestationsEndocrine DisrupterEndocrine Disrupting ChemicalsEndocrine DisruptorsEndocrine Gland SecretionEndocrine System DiseasesEndocrine disrupting agentEnvironmental ToxinEquilibriumExposure toFibrous DysplasiaFractureFracture HealingFunctional disorderG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG(s), alpha SubunitG(s), α SubunitG(s)alphaG(s)αG-Protein-Coupled ReceptorsGPCRGTP-Binding Protein alpha Subunits, GsGTP-Binding Protein α Subunits, GsGeneral PopulationGeneral PublicGoalsGs alpha Family G-ProteinGsαGαsHealthHearing LossHepatic DisorderHip FracturesHormonalHormonesHypercalcemiaHypoacusesHypoacusisHypophosphatemiaImpairmentIndividualIntermediary MetabolismInterventionIntervention TrialInterventional trialInvestigatorsJaffe-Lichtenstein syndromeKidney FailureKidney InsufficiencyKnowledgeLeadLesionLifelong disabilityLigandsLiver diseasesMalabsorption SyndromesMalnutritionManaged CareMcCune Albright's SyndromeMcCune-Albright SyndromeMetabolic Bone DiseasesMetabolic ProcessesMetabolismMissionModel SystemModelingMolecular InteractionMorbidityMorbidity - disease rateMosaicismNIDCRNIDRNational Institute of Dental ResearchNational Institute of Dental and Craniofacial ResearchNational Institutes of HealthNatural HistoryNutritionalNutritional DeficiencyOPGLOrphan DiseaseOrthodonticOsteoclastsPainPainfulPathogenesisPathogenicityPatientsPb elementPermanent disabilityPersistent disabilityPhase 2 Clinical TrialsPhase II Clinical TrialsPhenotypePhosphatesPhysical activityPhysiologicPhysiologicalPhysiologyPhysiopathologyPopulationPreventionProliferatingQOLQuality of lifeRANKLRadiographyRare DiseasesRare DisorderRegulatory Ns ProteinRenal FailureRenal InsufficiencyReportingResearch PersonnelResearch ResourcesResearch SpecimenResearchersResourcesRoentgenographyRoleSafetyShapesSignal PathwaySkeletal DevelopmentSkeletonSkullSpecimenStimulatory Gs G-ProteinStructureSurrogate End PointsSurrogate EndpointTMJ SyndromeTNFSF11TNFSF11 geneTemporomandibular Joint Dysfunction SyndromeTemporomandibular Joint Myofascial Pain Dysfunction SyndromeTemporomandibular Joint SyndromeTemporomandibular joint dysfunctionTherapeutic HormoneTimeToxic Environmental AgentsToxic Environmental SubstancesTreatment PeriodTreatment ProtocolsTreatment RegimenTreatment ScheduleUndernutritionUnited States National Institutes of HealthVariantVariationWorkabove age 65adenosine 3'5' monophosphateadolescent welfareadulthoodafter age 65age 65 and greaterage 65 and olderage 65 or olderageage of 65 years onwardaged 65 and greateraged 65+aged ≥65alpha Subunit Stimulatory GTP-Binding Proteinalpha-Gsbalancebalance functionbiobankbiorepositorybonebone disorderbone fracturebone fracture healingbone fracture repairbone metabolism disorderbone repairbone turnovercAMPchild well beingchild wellbeingchronic disorderchronic painclinical centercohortcostcraniofacialcraniofacial developmentcraniofacial disordercraniofaciescraniumdata interpretationdevelop therapydevelopmentaldietary deficiencydisabilitydysfunctional hearingeffective therapyeffective treatmentendocrine disorderendocrine disrupting compoundenvironmental toxicantexperiencefracture repairfracture riskfunctional disabilitygain of function mutationgastrointestinalgastrointestinal absorption disorderhRANKL2hearing challengedhearing defecthearing deficienthearing deficithearing difficultyhearing dysfunctionhearing impairmentheavy metal Pbheavy metal leadhepatic diseasehepatopathyhuman old age (65+)improvedinhibitorinorganic phosphateinsightintervention developmentintestinal malabsorptionkidsliver disordermalabsorptionmalnourishedmetabolic bone diseasemetabolic bone disordermineralizationmosaic diseasesmosaic disordersnovelnutrition deficiencynutrition deficiency disordernutritional deficiency disordernutritiousorphan disorderosteoblast progenitorosteoblast stem cellosteogenic progenitorosteogenic stem cellosteoprogenitorosteoprogenitor cellover 65 yearspathophysiologypediatricphase 2 trialphase II protocolphase II trialprematureprematuritypreventpreventingprogenitor cell proliferationprogenitor proliferationradiological imagingrecruitsOdfskeletalskeletal diseaseskeletal disorderskeletal progenitorskeletal progenitor cellskeletal stem cellskeletonssocial rolestandard of carestem and progenitor cell proliferationstem cell proliferationtemporomandibular dysfunction syndrometemporomandibular joint-pain-dysfunction syndrometherapeutic targettherapy developmenttooltranslational studytreatment daystreatment developmenttreatment durationtreatment strategyvision lossvisual lossyoungsteryouth sportsα-Gs≥65 years
Description preview
Our work focuses on craniofacial and associated skeletal disorders, which account for the leading causes of disability affecting individuals in America and worldwide. We utilize the mosaic disorder fibrous dysplasia/McCune-Albright syndrome (FD/MAS) as a model to inform understanding of the pathogenesis and treatment of these disorders. In FD/MAS,…
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