grant
Metabolic and xenobiotic control of thyroid hormone metabolism
Organization UNIVERSITY OF TEXAS MED BR GALVESTONLocation GALVESTON, UNITED STATESPosted 15 Jan 2025Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY202621+ years old3C-based approach3C-based assay3C-based method3C-based strategy3C-based technique3C-based technologyAdultAdult HumanAffectAreaBlood PlasmaBody TissuesBrown Adipose TissueBrown FatCell Communication and SignalingCell SignalingChromatinChromatin StructureChromosome 4CochleaCochlear OrganDNADNA MethylationDataDeiodinaseDeoxyribonucleic AcidDevelopmentEmbryoEmbryonicEnhancersEnzyme GeneEnzymesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExhibitsFatty LiverFundingFutureGene Down-RegulationGene ExpressionGene InactivationGene SilencingGene TranscriptionGenesGenetic TranscriptionGenomeHepaticHepatic CellsHepatic Parenchymal CellHepatocyteHeterochromatinHibernating GlandHumanHyperlipemiaHyperlipidemiaHypermethylationIntracellular Communication and SignalingIodide PeroxidaseIodinaseIodoperoxidase (Heme Type)Iodotyrosine DeiodaseIodotyrosine DeiodinaseIsoformsL-TriiodothyronineLearningLiothyronineLiverLiver CellsLiver SteatosisMediatingMetabolicMethylationMiceMice MammalsModern ManMonodeiodinaseMonoiodotyrosine DeiodinaseMurineMusNeonatalObesityOrganOrganoidsPerinatalPeripartumPhenotypePhysiologicPhysiologic pulsePhysiologicalPlasmaPlasma SerumPlayPredispositionProductionProtein IsoformsPulseRNA ExpressionRNA SeqRNA sequencingRNAseqReticuloendothelial System, Serum, PlasmaRoleShapesSignal TransductionSignal Transduction SystemsSignalingSiteSusceptibilityT-3T3 Thyroid HormoneTherapeutic T3Therapeutic TriiodothyronineThyroid CrisisThyroid Gland HormoneThyroid Hormone ReceptorThyroid HormonesThyroid PeroxidaseThyroid StormThyroperoxidaseThyrotoxic CrisisThyrotoxic StormTimeTissuesTranscriptionTranscription RepressionTriiodothyronineTyrosine IodinaseXenobioticsadiposityadulthoodbiological signal transductionchromatin conformation capturechromatin remodelingchromosome capturechromosome conformation captureco-repressorcorepressorcorpulencedevelopmentalepigeneticallyfascinatefat metabolismgene co-repressorgene corepressorgene repressiongenetic co-repressorgenetic corepressorglobal gene expressionglobal transcription profilehepatic body systemhepatic organ systemhepatic steatosishepatosteatosishormonal signalshormone metabolismhormone signalsknock-downknockdownlipid metabolismliver developmentnovelpostnatalpreventpreventingpromoterpromotorsocial roletranscriptional silencingtranscriptometranscriptome sequencingtranscriptomic sequencing
Description preview
ABSTRACT
Thyroid hormones (TH) play a critical role in development. In the embryo, plasma T3 is relatively low but
TH signaling can be enhanced by expression of Dio2, the deiodinase that mediates local T3 production. The
timing of the D2-T3 activation varies among tissues, e.g. embryonic day 17 (E17) in brown adipose tissue
(BAT), or post-natal…
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