grant
Metabolic adaptations to crisantaspase treatment mediated by the pancreatic ductal adenocarcinoma
Organization WEST VIRGINIA UNIVERSITYLocation MORGANTOWN, UNITED STATESPosted 1 Jul 2025Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025ASP-1AddressAlanineAmino Acid BiosynthesisAmino AcidsAmino Acids ActivationAsparaginase IIAsparagineAsparagine DeaminaseAssayAutophagocytosisAutoregulationBioassayBiological AssayBlood PlasmaBlood erythrocyteCancer CauseCancer EtiologyCancersCell BodyCell CommunicationCell Communication and SignalingCell InteractionCell LineCell ProtectionCell SignalingCell SurvivalCell ViabilityCell-to-Cell InteractionCellLineCellsCellular ExpansionCellular GrowthCessation of lifeCitric Acid CycleClinicalClinical TrialsCo-cultureCocultivationCocultureCoculture TechniquesColaspaseCytoprotectionDataDeathDiseaseDisorderE coliE. coliEffectivenessElsparEncapsulatedEnzyme GeneEnzymesErwinia chrysanthemiErythrocytesErythrocyticEscherichia coliEvaluationFunding MechanismsFutureGene ExpressionGeneralized GrowthGenerationsGlnGlutamineGlycolysisGoalsGrowthHomeostasisHumanImmuneImmunesIntermediary MetabolismIntracellular Communication and SignalingKidrolaseKrebs CycleL asparagine amidohydrolaseL-ASPL-AsparaginaseL-AsparagineL-GlutamineL-SerineLcf-ASPLipidsMalignant NeoplasmsMalignant TumorMarrow erythrocyteMediatingMembrane TransportMetabolicMetabolic PathwayMetabolic ProcessesMetabolismMiceMice MammalsMitochondriaModelingModern ManMurineMusNutrientOperative ProceduresOperative Surgical ProceduresOutcomeOxidation-ReductionPDA modelPDAC ModelPDAC cancer cellPDAC cellPancreas Ductal AdenocarcinomaPancreatic Ductal AdenocarcinomaPathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPectobacterium chrysanthemiPhasePhysiological HomeostasisPlasmaPlasma SerumPrognosisProgression-Free SurvivalsPublishingQ LevoglutamideQ. LevoglutamideRed Blood CellsRed CellRedoxRegimenReportingResearchResearch SpecimenResectedResistanceReticuloendothelial System, Serum, PlasmaSalvage TherapySalvage-TxSerasaSerineShort interfering RNASignal TransductionSignal Transduction SystemsSignalingSmall Interfering RNASpecimenStrains Cell LinesStromal CellsSurgicalSurgical InterventionsSurgical ProcedureTCA cycleTestingTherapeuticTimeTissue GrowthTransmembrane TransportTricarboxylic Acid CycleTumor ImmunityUnited StatesWorkaminoacidaminoacid biosynthesisanti-canceranti-tumor immunityantitumor immunityasparaginaseautophagybiological signal transductionblood corpusclescancer cell metabolismcancer immunitycancer metabolismcancer microenvironmentcancer progressioncell growthcell typechemotherapyclinical effectclinical relevanceclinically relevantcombatcultured cell linecytoprotectivedeprivationexosomeextracellularimprovedinhibitorinsightleukemiamalignancymetabolomemetabonomemitochondrialmouse modelmurine modelneoplasm progressionneoplasm/cancerneoplastic progressionnew approachesnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel approachesnovel strategiesnovel strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachontogenyoxidation reduction reactionpancreatic ductal adenocarcinoma cellpancreatic ductal adenocarcinoma modelpancreatic stellate cellpathwaypatient oriented outcomespharmacologicphase 3 trialphase III trialresistance mechanismresistantresistant mechanismresponseresponse to therapyresponse to treatmentsiRNAstable isotopesuccesssurgerysurvival outcometargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic responsetherapy responsetreatment responsetreatment responsivenesstumortumor cell metabolismtumor growthtumor metabolismtumor microenvironmenttumor progression
Description preview
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease without meaningful therapeutic options beyond
the first salvage therapy. Targeting PDAC metabolism through amino acid restriction has emerged as a promising new
strategy, with asparaginases, enzymes that deplete plasma glutamine and asparagine, reaching clinical trials.
Although a…
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