grant
Metabolic Actions of Glucagon
NIHUS FederalResearch GrantFY2025AcuteAdrenalineAdrenergic AgentsAdrenergic DrugsAdrenergicsAdult-Onset Diabetes MellitusAlpha CellAmino AcidsAntidiabetic HormoneAutomobile DrivingAutoregulationBeta CellBiologyBlood GlucoseBlood SugarBody Weight decreasedBrittle Diabetes MellitusCell CommunicationCell Communication and SignalingCell InteractionCell SignalingCell-to-Cell InteractionChronicClinicalComplexDataDiabetes MellitusDrug TargetingEndocrine Gland SecretionEpinephrineEquilibriumEventFastingFatty LiverG(s), alpha SubunitG(s), α SubunitG(s)alphaG(s)αG-ProteinsGTP-Binding Protein alpha Subunits, GsGTP-Binding Protein α Subunits, GsGTP-Binding ProteinsGTP-Regulatory ProteinsGenerationsGlucagonGlucagon CellGlucagon ReceptorGlucagon Secreting CellGluconeogenesisGlukagonGs alpha Family G-ProteinGsαGuanine Nucleotide Coupling ProteinGuanine Nucleotide Regulatory ProteinsGαsHG-FactorHepaticHepatic CellsHepatic DisorderHepatic Parenchymal CellHepatocyteHomeostasisHormonesHumulin RHyperglycemiaHyperglycemic-Glycogenolytic FactorHypoglycemiaIDDMInsulinInsulin CellInsulin Secreting CellInsulin Signaling PathwayInsulin-Dependent Diabetes MellitusIntermediary MetabolismIntracellular Communication and SignalingInvestigationInvestigatorsJuvenile-Onset Diabetes MellitusKetosis-Prone Diabetes MellitusKetosis-Resistant Diabetes MellitusKnock-outKnockoutKnowledgeLiverLiver CellsLiver SteatosisLiver diseasesMaturity-Onset Diabetes MellitusMediatingMetabolicMetabolic ProcessesMetabolismMiceMice MammalsModelingMolecularMurineMusNIDDMNatureNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNovolin RNutrientObesityPathway interactionsPeptidesPharmacologyPhysiologicPhysiologicalPhysiological HomeostasisPhysiologyPositionPositioning AttributePreventionReceptor ActivationReceptor SignalingRegular InsulinRegulatory Ns ProteinResearch PersonnelResearchersRoleRunningSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSignaling Factor Proto-OncogeneSignaling Pathway GeneSignaling ProteinSiteSlow-Onset Diabetes MellitusStable Diabetes MellitusStimulatory Gs G-ProteinSudden-Onset Diabetes MellitusT1 DMT1 diabetesT1DT1DMT2 DMT2DT2DMTestingTherapeuticTherapeutic EpinephrineTherapeutic HormoneType 1 Diabetes MellitusType 1 diabetesType 2 Diabetes MellitusType 2 diabetesType I Diabetes MellitusType II Diabetes MellitusType II diabetesWeight LossWeight ReductionWorkadiposityadult onset diabetesalpha Subunit Stimulatory GTP-Binding Proteinalpha-Gsalpha-cellaminoacidantagonismantagonistarrestin Bbalancebalance functionbeta-arrestinbiological signal transductionblood glucose regulationbody weight losscorpulencecounterregulationdevelop therapydiabetesdrivingexperimentexperimental researchexperimental studyexperimentsfastedfastsfat metabolismglucose RAglucose biosynthesisglucose controlglucose homeostasisglucose metabolismglucose productionglucose rate of appearanceglucose regulationglycemic controlhepatic body systemhepatic diseasehepatic organ systemhepatic steatosishepatopathyhepatosteatosishuman subjecthyperglycemichypoglycemichypoglycemic episodesinsulin dependent diabetesinsulin dependent type 1insulin sensitivityinsulin signalingintervention developmentisletjuvenile diabetesjuvenile diabetes mellitusketosis prone diabetesketosis resistant diabeteslipid metabolismliver disordermaturity onset diabetesmouse modelmurine modelnovelpathwaypharmacologicpressurepreventpreventingside effectsocial roletherapy developmenttranslational opportunitiestranslational potentialtreatment developmenttype 1 and type 2 diabetestype 2 DMtype I and type II diabetestype I diabetestype II DMtype one diabetestype two diabeteswt-lossα-Gsα-cellβ-arrestinβ-cellβ-cellsβCell
Description preview
Summary of Work
Glucagon is canonically viewed as an essential counterregulatory hormone that prevents hypoglycemia by driving
endogenous glucose production (EGP) in the liver. We and others have revealed additional roles for glucagon
that emphasize a much more complex control of metabolism beyond hypoglycemia. For instance, glucagon is a
potent…
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