grant
Mentoring patient-oriented translational research in tuberculosis
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 11 Apr 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY2025AccelerationAdverse ExperienceAdverse eventAmericasAntigensAntitubercular DrugsAssayAwardBackBenchmarkingBest Practice AnalysisBioassayBiological AssayBrazilCOVID crisisCOVID epidemicCOVID pandemicCOVID-19 crisisCOVID-19 epidemicCOVID-19 eraCOVID-19 global health crisisCOVID-19 global pandemicCOVID-19 health crisisCOVID-19 pandemicCOVID-19 periodCOVID-19 public health crisisCOVID-19 yearsCYP3A5CYP3A5 geneCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesCause of DeathCessation of lifeClinical ResearchClinical StudyClinical TrialsCollaborationsCommunicable DiseasesCytochrome P450, Subfamily IIIA, Polypeptide 5DNADeathDeoxyribonucleic AcidDetectionDevelopmentDiagnosisDorsumDoseDrug KineticsDrug Resistance TuberculosisDrug Resistant TBDrug Resistant TuberculosisDrug resistance in tuberculosisDrug toxicityDrug usageDrugsEarly DiagnosisEnzyme GeneEnzymesExhalationExhalingFocus GroupsFundingGene ExpressionGene TranscriptionGenetic PolymorphismGenetic TranscriptionGenomicsGoalsHaplotypesHealth Care FacilityHealth FacilitiesHomeHumanImmunoassayImprisonmentIncidenceIndividualInfectious DiseasesInfectious DisorderIntermediary MetabolismInvestigatorsIsonicotinic Acid HydrazideK-AwardsK-Series Research Career ProgramsK24 AwardLaboratoriesLinezolidLipidsLow-resource areaLow-resource communityLow-resource environmentLow-resource regionLow-resource settingM tbM tuberculosisM tuberculosis antigenM tuberculosis infectionM. tbM. tb infectionM. tuberculosisM. tuberculosis antigenM. tuberculosis infectionM.tb antigenM.tb infectionM.tuberculosis infectionMDR TuberculosisMDR-TBMTB infectionMeasuresMedicationMentorsMentorshipMetabolic ProcessesMetabolismMid-Career Clinical Scientist Award (K24)Modern ManMorbidityMorbidity - disease rateMtb antigenMulti-Drug Resistant TuberculosisMultiDrug Resistance TuberculosisMultidrug-Resistant TuberculosisMycobacterium tuberculosisMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis antigensMycobacterium tuberculosis infectionNational Institutes of HealthOralP450PCN3ParticipantPatient SelectionPatientsPharmaceutical PreparationsPharmacogenomicsPharmacokineticsPhysical condensationPhysiciansPilot ProjectsPostdocPostdoctoral FellowPredicting RiskPreventative therapyPreventative treatmentPreventionPrevention MeasuresPreventive therapyPreventive treatmentPrisonsProteinsRNA ExpressionRegimenResearchResearch AssociateResearch Career ProgramResearch PersonnelResearchersResource-constrained areaResource-constrained communityResource-constrained environmentResource-constrained regionResource-constrained settingResource-limited areaResource-limited communityResource-limited environmentResource-limited regionResource-limited settingResource-poor areaResource-poor communityResource-poor environmentResource-poor regionResource-poor settingRespiratory ExpirationRifampicin resistanceRifampicin resistantRifampin resistanceRifampin resistantRiskRoentgen RaysSARS-CoV-2 epidemicSARS-CoV-2 global health crisisSARS-CoV-2 global pandemicSARS-CoV-2 pandemicSARS-coronavirus-2 epidemicSARS-coronavirus-2 pandemicSamplingScientistSevere Acute Respiratory Syndrome CoV 2 epidemicSevere Acute Respiratory Syndrome CoV 2 pandemicSevere acute respiratory syndrome coronavirus 2 epidemicSevere acute respiratory syndrome coronavirus 2 pandemicSpecificitySputumStudentsTB diagnosisTB drug resistanceTB drugsTB infectionTB resistanceTB therapyTB treatmentTestingTimeToxic effectToxicitiesTrainingTranscriptionTranslational ResearchTranslational ScienceTransmissionTuberculosisTuberculosis diagnosisUnited States National Institutes of HealthVariantVariationX-RadiationX-Ray RadiationX-rayXrayZyvoxadverse event riskanti-TB drugsanti-tuberculosis drugsantigen based detectionantigen detectionbenchmarkcare facilitiescare seekingcareercase findingcohortcondensationcoronavirus disease 2019 crisiscoronavirus disease 2019 epidemiccoronavirus disease 2019 global health crisiscoronavirus disease 2019 global pandemiccoronavirus disease 2019 health crisiscoronavirus disease 2019 pandemiccoronavirus disease 2019 public health crisiscoronavirus disease crisiscoronavirus disease epidemiccoronavirus disease pandemiccoronavirus disease-19 global pandemiccoronavirus disease-19 pandemiccostdetect antigendetection assaydevelopmentaldiagnosed with TBdiagnosed with Tuberculosisdisseminated TBdisseminated tuberculosisdrug metabolismdrug resistance in TBdrug resistant in tuberculosisdrug usedrug/agentearly detectioneffective therapyeffective treatmentforecasting riskhigh risk grouphigh risk individualhigh risk peoplehigh risk populationhomesimmunogenimprovedincarceratedincarcerationinfection due to Mycobacterium tuberculosisinnovateinnovationinnovativeisoniazidlipoarabinomannanmortalitymtbmultidrug-resistant TBnano porenanoporenew approachesnext generationnovelnovel approachesnovel strategiesnovel strategypatient centeredpatient orientedpatient oriented researchpatient oriented studypersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentpilot studypolymorphismpost-docpost-doctoralpost-doctoral traineepredict riskpredict riskspredicted riskpredicted riskspredicting riskspredictive riskpredicts riskpreventpreventingresearch associatesresistance in TBresistance in tuberculosisresistance to rifampicinresistance to rifampinresistant TBresistant to rifampicinresistant to rifampinresistant tuberculosisrifapentinerisk predictionrisk predictionsscreeningscreeningssevere acute respiratory syndrome coronavirus 2 global health crisissevere acute respiratory syndrome coronavirus 2 global pandemicskillstargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapy optimizationtooltranslation researchtranslational investigationtranslational studytransmission processtreat M. tuberculosistreat Mtbtreat Mycobacterium tuberculosistreat tbtreat tuberculosistreatment optimizationtuberculosis drugstuberculosis infectiontuberculosis resistancetuberculosis therapytuberculosis treatmenttuberculous spondyloarthropathyvirtual
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Project Summary
Tuberculosis remains one of the leading causes of death worldwide, despite the widespread availability of
effective treatment and prevention measures. To accelerate progress in reducing the global burden of
tuberculosis, there is a need for new tools and approaches to identify TB early, treat it effectively, minimizing
toxicities,…
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