grant

Membrane-inspired lipid nanoparticles for cell-type-specific expression of programmable RNA

Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2031
NIHUS FederalResearch GrantFY2026Advanced DevelopmentCNS Nervous SystemCapsidCell BodyCell FunctionCell PhysiologyCell ProcessCell membraneCellsCellular FunctionCellular PhysiologyCellular ProcessCentral Nervous SystemCytoplasmic MembraneDevelopmentDevelopment and ResearchEncapsulatedEngineeringFormulationGene DeliveryGene ExpressionGoalsImaging ProceduresImaging TechnicsImaging TechniquesIn VitroLipidsMembraneMolecularNanotechnologyNeuraxisNeurosciencesNon-Polyadenylated RNAOrganPeripheralPlasma MembranePopulationPrecision therapeuticsProductionPropertyR & DR&DRNARNA Gene ProductsRibonucleic AcidSpecificitySubcellular ProcessSystemTranscriptTransfectionViralViral Vectorbiological researchbiophysical approachesbiophysical methodologybiophysical methodsbiophysical techniquescell typedesigndesigningdevelopmentalimmunogenicityin vivoinnovateinnovationinnovativeinterdisciplinary approachlipid based nanoparticlelipid nanoparticlemembrane structuremultidisciplinary approachnano technano technologynano-technologicalnanotechnanotechnologicalnext generationnovelplasmalemmaprecision therapiesprecision treatmentpromoterpromotorresearch and developmentsensorsynthetic biologytransgene expression
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Project Summary/Abstract
Precise delivery of biomolecules to specific cell types is essential for elucidating cellular functions and advancing
precision molecular therapies. While viral vectors have achieved significant advances in targeted gene delivery
through capsid engineering and cell-type-specific promoters, they are limited by…

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Membrane-inspired lipid nanoparticles for cell-type-specific expression of programmable RNA — UNIVERSITY OF CALIFORNIA, | Dev Procure