grant
Melanocortin-3 receptor in feeding and anxiety neural circuits
Organization UNIVERSITY OF FLORIDALocation GAINESVILLE, UNITED STATESPosted 3 Apr 2025Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY202621+ years old3-D Images3-D image3D image3D imagesAdultAdult HumanAnatomic SitesAnatomic structuresAnatomyAnorexiaAnxietyAnxiety DisordersAreaAutomobile DrivingAutoregulationBed Nucleus of Stria TerminalisBehaviorBehavioralBinge eating disorderBody TissuesBrainBrain Nervous SystemBrain StemBrainstemCell BodyCell Communication and SignalingCell NucleusCell SignalingCellsClinicalCommunicationComplexCuesDevelopmentDifferences between sexesDiffers between sexesDiseaseDisorderEatingEating DisordersEmotionalEncephalonExperimental GeneticsExposure toFailureFeeding behaviorsFemaleFiberFood EnergyFood IntakeHealthHeterogeneityHigh Fat DietHomeostasisHypothalamic structureHypothalamusImage AnalysesImage AnalysisImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodIndividualIngestive BehaviorInstructionIntracellular Communication and SignalingLactationLinkMC3 ReceptorMapsMediatingMelanocortin 3 ReceptorMental disordersMental health disordersMetabolic DiseasesMetabolic DisorderMethodsMiceMice MammalsMurineMusNerve CellsNerve UnitNeural CellNeurocyteNeuroendocrineNeuroendocrine SystemNeurologicNeurologicalNeuronsNeurosecretory SystemsNuclearNucleusObesityOrganism-Level ProcessOrganismal ProcessOutputOverweightPathologicPathological anxietyPhasePhenotypePhotometryPhysiologic ProcessesPhysiological HomeostasisPhysiological ProcessesPopulationPositionPositioning AttributePredispositionPrevalenceProcessPsychiatric DiseasePsychiatric DisorderPsychopathologyReceptor, Melanocortin, Type 3RegulationRoleSex DifferencesSexual differencesSignal TransductionSignal Transduction SystemsSignalingSiteSocial isolationStressStria Terminalis NucleusStructureStructure of terminal stria nuclei of preoptic regionSusceptibilitySystemTechniquesTestingThesaurismosisThree-Dimensional ImageTimeTissuesTrainingViralViral GeneticsWorkabnormal psychologyadiposityadulthoodanorexicanxiety-like behaviorbiological signal transductioncorpulencecritical perioddevelopmentaldietarydrivingdriving behaviorearly life stressenergy balanceexperienceexperimentexperimental researchexperimental studyexperimentsfeedingfeeding-related behaviorsfood Ingestionfood avoidancefood consumptiongene manipulationgenetic manipulationgenetically manipulategenetically perturbhypothalamicimage evaluationimage interpretationin vivolactatinglactationallarge data setslarge datasetsmalemental illnessmetabolism disordermotivated behaviorneuralneural circuitneural circuitryneurocircuitryneuronalnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapynutrient intake activitypsychiatric illnesspsychological disorderreceptor expressionresponserestraint stresssevere anxietysexsex based differencessex dimorphismsex-dependent differencessex-related differencessex-specific differencessexual dimorphismsexually dimorphicsocial rolestressorsynaptic circuitsynaptic circuitryvirus genetics♀♂
Description preview
PROJECT SUMMARY (See instructions):
Neural circuits modulating feeding, stress and anxiety must communicate with each other to maintain homeostasis.
Failure to appropriately respond to certain stressors can promote the development of maladaptive feeding behaviors
observed with obesity and metabolic disorders. Despite an increasing prevalence of…
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