grant
Medicinal Chemistry Core
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 1 Aug 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY2025AccelerationAddressAnimal ModelAnimal Models and Related StudiesAreaAssayBioassayBiochemicalBiological AssayBody TissuesCaspofunginChemicalsChemistryClinicalCompetenceCrystallizationDataDevelopmentDrug Discovery GroupsDrug IndustryDrug KineticsDrug TargetingDrug resistanceDrugsEvaluationEvolutionFilamentous FungiFormulationHealthHistoryHumanHuman ResourcesIndividualIndustrializationIndustryLeadLeadershipMachine LearningManpowerMedicationMedicinal ChemistryMedicineMinimum Inhibitory Concentration measurementMinimum Inhibitory ConcentrationsModern ManMoldsMycologyNatural ProductsNatural Products ChemistryPb elementPharmaceutic ChemistryPharmaceutic IndustryPharmaceutical AgentPharmaceutical ChemistryPharmaceutical IndustryPharmaceutical PreparationsPharmaceuticalsPharmacodynamicsPharmacokineticsPharmacologic SubstancePharmacological SubstancePharmacologyPropertyRecording of previous eventsResearchResearch ResourcesResourcesSeriesSodium ChlorideSolubilityStructureStructure-Activity RelationshipSynthesis ChemistrySynthetic ChemistryTechniquesThe science of MycologyTherapeutic FungicidesTissuesToxic effectToxicitiesToxicologyTranslationsUrinary tractYeastsanaloganti-fungalanti-fungal agentsanti-fungal drugcandidate identificationchemical informaticschemical resourcechemical structure functioncheminformaticscostdesigndesigningdevelopmentaldrug candidatedrug developmentdrug discoverydrug resistantdrug/agentefficacy studyexperiencefungal pathogenfungi pathogengenotoxicityglobal healthglucan synthaseheavy metal Pbheavy metal leadhistoriesinhibitorinsightlead optimizationlead seriesmachine based learningmachine learning based modelmachine learning modelmeetingmeetingsmembermodel of animalmouse modelmurine modelnaturally occurring productnovelpathogenic funguspersonnelpharmaceuticalpre-clinicalpre-clinical developmentpreclinicalpreclinical developmentprocess optimizationprogramsresistance to Drugresistant to Drugsaltscale upscreeningscreeningssmall moleculestructure function relationshiptechnology platformtechnology systemtooltranslation
Description preview
SUMMARY
The Medicinal Chemistry Core (MCC) will provide synthetic and medicinal chemistry, cheminformatics, and
structure-based design resources complementary to those existing within the respective project teams. It will
integrate tightly with the other Cores. The MCC resource will distinguish itself by relying on extensive
pharmaceutical…
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